STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cct2Thermosome subunit 2; Molecular chaperone that assists in the folding or refolding of nascent or denatured proteins along with ATP hydrolysis (Probable). ATPase activity is highest in thermosome assemblies containing CCT1:CCT2, followed by assemblies containing CCT1:CCT2:CCT3. Seems to contribute to thermosome ATPase activity. Not required for growth; Belongs to the TCP-1 chaperonin family (547 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone
  
 
 0.886
rpoA1
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  
 
 0.786
rpoB1
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  
  
 0.749
rpl22p
50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
  
 
 0.740
rplP0
50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
  
 
 0.726
psmA2
Proteasome subunit alpha 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The H.volcanii alpha1-beta-alpha2 proteasome is able to cleave oligopeptides after Tyr and thus displays chymotrypsin-like activity
  
 
 0.726
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent [...]
  
 
 0.725
rpl4lp
50S ribosomal protein L4; Forms part of the polypeptide exit tunnel
 
 
 0.725
psmA1
Proteasome subunit alpha 1; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The H.volcanii alpha1-beta proteasome is able to cleave oligopeptides after Phe, Tyr and Trp, poorly after Glu but not after Arg. Thus, displays chymotrypsin-like activity, low caspase- like activity but no trypsin-like activity; Belongs to the peptidase T1A family
  
 
 0.725
rpl10e
COG0197 Ribosomal protein L16/L10E; Belongs to the universal ribosomal protein uL16 family
  
 
 0.723
Your Current Organism:
Haloferax volcanii
NCBI taxonomy Id: 309800
Other names: H. volcanii DS2, Haloferax volcanii, Haloferax volcanii ATCC 29605, Haloferax volcanii DS2, Haloferax volcanii DSM 3757, Haloferax volcanii str. DS2, Haloferax volcanii strain DS2
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