STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aglMUDP-glucose 6-dehydrogenase AglM; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Involved in the biosynthesis of the hexuronic acids found at both positions 2 and 3 of the pentasaccharide; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (430 aa)    
Predicted Functional Partners:
HVO_1576
GalE family epimerase/dehydratase.
 0.990
agl13
dTDP-4-dehydrorhamnose 3,5-epimerase; Epimerase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at 'Asn- 532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
  
  
 0.984
agl11
Glucose-1-phosphate thymidylyltransferase Agl11; Nucleotidyltransferase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier.
  
  
 0.984
agl12
dTDP-glucose 4,6-dehydratase; Lyase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier.
 
  
 0.980
HVO_1172
GalE family epimerase/dehydratase.
 
 0.958
aglR
Putative flippase AglR; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Probably mediates or contributes to the translocation of the dolichol-phosphate-mannose across the membrane; Belongs to the AglR/Agl15 family.
  
  
 0.906
aglF
Glucose-1-phosphate uridylyltransferase; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Involved in the biosynthesis of the hexuronic acid found at position 3 of the pentasaccharide; Belongs to the UDPGP type 2 family.
  
  
 0.863
agl15
Putative low-salt glycan biosynthesis flippase Agl15; Flippase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Probably moves the tetrasaccharide from the cytosolic to the extracytosolic side of the membrane.
  
  
 0.826
HVO_2040
GalE family epimerase/dehydratase.
 
 0.817
sgb
Putative transport protein (probable polysaccharide biosynthesis transport protein).
  
  
 0.814
Your Current Organism:
Haloferax volcanii
NCBI taxonomy Id: 309800
Other names: H. volcanii DS2, Haloferax volcanii ATCC 29605, Haloferax volcanii DS2, Haloferax volcanii DSM 3757, Haloferax volcanii str. DS2, Haloferax volcanii strain DS2
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.