node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HVO_1016 | cdc48b | HVO_1016 | HVO_2700 | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | AAA-type ATPase (CDC48 subfamily). | 0.434 |
HVO_1016 | glpK | HVO_1016 | HVO_1541 | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. It also catalyzes the phosphorylation of dihydroxyacetone (DHA). Involved, together with the DHA kinase DhaKLM, in the metabolism of DHA. | 0.936 |
HVO_1016 | jamm1 | HVO_1016 | HVO_2505 | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | Metalloprotease JAMM1, desampylating; Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked). Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification. Functions as a specific and not a general protease since it is unable to hydrolyze a variety of unmodified proteins otherwise hydrolyzed by proteinase K. | 0.540 |
HVO_1016 | panA | HVO_1016 | HVO_0850 | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- terminus of the proteasomal ATPase functions like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPas [...] | 0.861 |
HVO_1016 | panB | HVO_1016 | HVO_1957 | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.861 |
HVO_1016 | psmA1 | HVO_1016 | HVO_1091 | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The H.volcanii alpha1-beta proteasome is able to cleave oligopeptides after Phe, Tyr and Trp, poorly after Glu but not after Arg. Thus, displays chymotrypsin-like activity, low caspase-like activity but no trypsin- like activity; Belongs to the peptidase T1A family. | 0.777 |
HVO_1016 | psmA2 | HVO_1016 | HVO_2923 | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The H.volcanii alpha1-beta-alpha2 proteasome is able to cleave oligopeptides after Tyr and thus displays chymotrypsin-like activity. | 0.777 |
HVO_1016 | psmB | HVO_1016 | HVO_1562 | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | Proteasome beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The H.volcanii alpha1-beta proteasome is able to cleave oligopeptides after Phe, Tyr and Trp, poorly after Glu but not after Arg. Thus, displays chymotrypsin-like activity, low caspase-like activity but no trypsin- like activity. | 0.777 |
HVO_1016 | rpl40e | HVO_1016 | HVO_0439 | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.933 |
cdc48b | HVO_1016 | HVO_2700 | HVO_1016 | AAA-type ATPase (CDC48 subfamily). | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | 0.434 |
cdc48b | glpK | HVO_2700 | HVO_1541 | AAA-type ATPase (CDC48 subfamily). | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. It also catalyzes the phosphorylation of dihydroxyacetone (DHA). Involved, together with the DHA kinase DhaKLM, in the metabolism of DHA. | 0.670 |
cdc48b | jamm1 | HVO_2700 | HVO_2505 | AAA-type ATPase (CDC48 subfamily). | Metalloprotease JAMM1, desampylating; Metalloprotease that displays desampylase (DSAMP) activity, cleaving ubiquitin-like small archaeal modifier proteins (SAMP1, SAMP2 and SAMP3) from protein conjugates (isopeptide- and linear-linked). Thus, likely regulates sampylation and the pools of 'free' SAMP available for protein modification. Functions as a specific and not a general protease since it is unable to hydrolyze a variety of unmodified proteins otherwise hydrolyzed by proteinase K. | 0.765 |
cdc48b | panA | HVO_2700 | HVO_0850 | AAA-type ATPase (CDC48 subfamily). | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- terminus of the proteasomal ATPase functions like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPas [...] | 0.576 |
cdc48b | panB | HVO_2700 | HVO_1957 | AAA-type ATPase (CDC48 subfamily). | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.546 |
cdc48b | psmA1 | HVO_2700 | HVO_1091 | AAA-type ATPase (CDC48 subfamily). | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The H.volcanii alpha1-beta proteasome is able to cleave oligopeptides after Phe, Tyr and Trp, poorly after Glu but not after Arg. Thus, displays chymotrypsin-like activity, low caspase-like activity but no trypsin- like activity; Belongs to the peptidase T1A family. | 0.546 |
cdc48b | psmA2 | HVO_2700 | HVO_2923 | AAA-type ATPase (CDC48 subfamily). | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The H.volcanii alpha1-beta-alpha2 proteasome is able to cleave oligopeptides after Tyr and thus displays chymotrypsin-like activity. | 0.600 |
cdc48b | psmB | HVO_2700 | HVO_1562 | AAA-type ATPase (CDC48 subfamily). | Proteasome beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The H.volcanii alpha1-beta proteasome is able to cleave oligopeptides after Phe, Tyr and Trp, poorly after Glu but not after Arg. Thus, displays chymotrypsin-like activity, low caspase-like activity but no trypsin- like activity. | 0.731 |
cdc48b | rpl40e | HVO_2700 | HVO_0439 | AAA-type ATPase (CDC48 subfamily). | 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. | 0.704 |
cdc48b | tbp2 | HVO_2700 | HVO_1727 | AAA-type ATPase (CDC48 subfamily). | TATA-binding transcription initiation factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). | 0.581 |
glpK | HVO_1016 | HVO_1541 | HVO_1016 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. It also catalyzes the phosphorylation of dihydroxyacetone (DHA). Involved, together with the DHA kinase DhaKLM, in the metabolism of DHA. | JAB domain protein; Probable metalloprotease. Does not hydrolyze SAMP1- and SAMP2-protein conjugates, diglycine-AMC, Ub-AMC, hemoglobin, cytochrome c, carbonic anhydrase, creatinine phosphokinase, beta-amylase and bovine serum albumin. | 0.936 |