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folD protein (Thermomicrobium roseum) - STRING interaction network
"folD" - Bifunctional protein FolD in Thermomicrobium roseum
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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folDBifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (288 aa)    
Predicted Functional Partners:
fhs
Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family (551 aa)
 
 
  0.994
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (426 aa)
 
 
  0.993
purH
Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355 (504 aa)
 
  0.985
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus (313 aa)
 
 
  0.971
trd_1049
5-methyltetrahydrofolate S-homocysteine methyltransferase; Identified by match to protein family HMM PF02219; match to protein family HMM PF02574 (624 aa)
   
 
  0.966
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (207 aa)
 
 
  0.965
trd_A0792
Identified by match to protein family HMM PF01571; Belongs to the GcvT family (468 aa)
   
 
  0.959
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (375 aa)
   
 
  0.959
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP (527 aa)
   
   
  0.929
trd_0899
Methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219 (299 aa)
   
 
  0.928
Your Current Organism:
Thermomicrobium roseum
NCBI taxonomy Id: 309801
Other names: T. roseum DSM 5159, Thermomicrobium roseum, Thermomicrobium roseum DSM 5159, Thermomicrobium roseum DSM5159
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