node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VF_0852 | hisB | VF_0852 | VF_1015 | Phenylalanine and histidine ammonia-lyase. | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.470 |
VF_0852 | hisD | VF_0852 | VF_1013 | Phenylalanine and histidine ammonia-lyase. | Bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.921 |
VF_0852 | hutH | VF_0852 | VF_A0450 | Phenylalanine and histidine ammonia-lyase. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.921 |
hisA | hisB | VF_1017 | VF_1015 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase. | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.996 |
hisA | hisC | VF_1017 | VF_1014 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.984 |
hisA | hisD | VF_1017 | VF_1013 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase. | Bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.985 |
hisA | hisF | VF_1017 | VF_1018 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase. | Imidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | VF_1017 | VF_1012 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.985 |
hisA | hisH | VF_1017 | VF_1016 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
hisA | hisI | VF_1017 | VF_1019 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase. | Fused phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | VF_0852 | VF_1015 | VF_0852 | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | Phenylalanine and histidine ammonia-lyase. | 0.470 |
hisB | hisA | VF_1015 | VF_1017 | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase. | 0.996 |
hisB | hisC | VF_1015 | VF_1014 | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | VF_1015 | VF_1013 | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | Bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | VF_1015 | VF_1018 | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | Imidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | VF_1015 | VF_1012 | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.995 |
hisB | hisH | VF_1015 | VF_1016 | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | VF_1015 | VF_1019 | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | Fused phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.997 |
hisB | hutH | VF_1015 | VF_A0450 | Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | Histidine ammonia-lyase; Belongs to the PAL/histidase family. | 0.470 |
hisC | hisA | VF_1014 | VF_1017 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase. | 0.984 |