node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
holD | mukB | VF_0498 | VF_A0432 | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | 0.423 |
holD | mukF | VF_0498 | VF_A0430 | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Calcium-binding protein involved in chromosome partioning; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. | 0.462 |
holD | seqA | VF_0498 | VF_0815 | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Regulatory protein for replication initiation; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.627 |
holD | tfoX1 | VF_0498 | VF_0896 | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | DNA transformation protein TfoX1 (Sxy); Required for DNA transformation jointly with TfoX2. | 0.743 |
holD | tfoX2 | VF_0498 | VF_1573 | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | DNA transformation protein TfoX2 (Sxy); Required for efficient DNA transformation jointly with TfoX1. Belongs to the TfoX family. | 0.542 |
holD | trpR | VF_0498 | VF_0559 | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | DNA-binding transcriptional repressor, tryptophan-binding; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription. | 0.595 |
holD | ycbG | VF_0498 | VF_1294 | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Conserved protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. | 0.802 |
holD | yfbU | VF_0498 | VF_1794 | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Conserved protein; Belongs to the UPF0304 family. | 0.670 |
holD | zapB | VF_0498 | VF_0210 | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | Transcriptional regulator; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.530 |
mukB | holD | VF_A0432 | VF_0498 | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. | 0.423 |
mukB | mukE | VF_A0432 | VF_A0431 | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | Protein involved in chromosome partitioning; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF. | 0.997 |
mukB | mukF | VF_A0432 | VF_A0430 | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | Calcium-binding protein involved in chromosome partioning; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. | 0.997 |
mukB | seqA | VF_A0432 | VF_0815 | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | Regulatory protein for replication initiation; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.796 |
mukB | tfoX1 | VF_A0432 | VF_0896 | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | DNA transformation protein TfoX1 (Sxy); Required for DNA transformation jointly with TfoX2. | 0.733 |
mukB | tfoX2 | VF_A0432 | VF_1573 | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | DNA transformation protein TfoX2 (Sxy); Required for efficient DNA transformation jointly with TfoX1. Belongs to the TfoX family. | 0.600 |
mukB | trpR | VF_A0432 | VF_0559 | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | DNA-binding transcriptional repressor, tryptophan-binding; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription. | 0.624 |
mukB | ycbG | VF_A0432 | VF_1294 | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | Conserved protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. | 0.952 |
mukB | yfbU | VF_A0432 | VF_1794 | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | Conserved protein; Belongs to the UPF0304 family. | 0.694 |
mukB | zapB | VF_A0432 | VF_0210 | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | Transcriptional regulator; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. | 0.742 |
mukE | mukB | VF_A0431 | VF_A0432 | Protein involved in chromosome partitioning; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF. | Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily. | 0.997 |