node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VF_1352 | folE | VF_1352 | VF_1607 | MutT/nudix family protein. | GTP cyclohydrolase I. | 0.911 |
VF_1352 | sscR | VF_1352 | VF_1160 | MutT/nudix family protein. | 6-pyruvoyl tetrahydrobiopterin synthase (PTPS). | 0.902 |
VF_2246 | folB | VF_2246 | VF_2247 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | Bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.998 |
VF_2246 | folE | VF_2246 | VF_1607 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | GTP cyclohydrolase I. | 0.900 |
VF_2246 | folK | VF_2246 | VF_2168 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase. | 0.922 |
VF_2246 | folP | VF_2246 | VF_0480 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.995 |
VF_2246 | ribB | VF_2246 | VF_0702 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.472 |
folB | VF_2246 | VF_2247 | VF_2246 | Bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.998 |
folB | folE | VF_2247 | VF_1607 | Bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase I. | 0.971 |
folB | folK | VF_2247 | VF_2168 | Bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase. | 0.993 |
folB | folP | VF_2247 | VF_0480 | Bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.995 |
folB | ribB | VF_2247 | VF_0702 | Bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.418 |
folE | VF_1352 | VF_1607 | VF_1352 | GTP cyclohydrolase I. | MutT/nudix family protein. | 0.911 |
folE | VF_2246 | VF_1607 | VF_2246 | GTP cyclohydrolase I. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.900 |
folE | folB | VF_1607 | VF_2247 | GTP cyclohydrolase I. | Bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.971 |
folE | folK | VF_1607 | VF_2168 | GTP cyclohydrolase I. | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase. | 0.994 |
folE | folP | VF_1607 | VF_0480 | GTP cyclohydrolase I. | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.961 |
folE | moaA | VF_1607 | VF_0940 | GTP cyclohydrolase I. | Molybdopterin biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.911 |
folE | ndk | VF_1607 | VF_0625 | GTP cyclohydrolase I. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.839 |
folE | ribA | VF_1607 | VF_1189 | GTP cyclohydrolase I. | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.968 |