STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rseBPeriplasmic sigmaE factor regulatory protein RseB. (308 aa)    
Predicted Functional Partners:
rseA
anti-sigmaE factor, inner membrane; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
 
 
 0.998
rseC
sigma-E factor regulatory protein RseC.
 
  
 0.990
rpoE
RNA polymerase, sigma-24 (sigma-E) factor; Belongs to the sigma-70 factor family. ECF subfamily.
 
 
 0.909
yafS
Predicted S-adenosyl-L-methionine-dependent methyltransferase.
  
     0.708
rseP
Membrane-associated zinc protease (RseP, YaeL).
  
  
 0.697
nlpB
Lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
     0.696
seqA
Regulatory protein for replication initiation; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.683
rpoE2
RNA polymerase ECF-type sigma factor; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.655
rpoE3
RNA polymerase ECF-type sigma factor; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.655
rpoE4
RNA polymerase ECF-type sigma factor; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.640
Your Current Organism:
Aliivibrio fischeri
NCBI taxonomy Id: 312309
Other names: A. fischeri ES114, Aliivibrio fischeri ES114, Vibrio fischeri ES114, Vibrio fischeri str. ES114, Vibrio fischeri strain ES114
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.