node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VF_2301 | gcvH | VF_2301 | VF_A0702 | Dihydrolipoamide dehydrogenase. | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.951 |
VF_2301 | gcvP | VF_2301 | VF_A0703 | Dihydrolipoamide dehydrogenase. | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.946 |
VF_2301 | gcvT | VF_2301 | VF_A0700 | Dihydrolipoamide dehydrogenase. | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex. | 0.926 |
VF_2301 | glyA | VF_2301 | VF_0695 | Dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.914 |
VF_2301 | lpd | VF_2301 | VF_2178 | Dihydrolipoamide dehydrogenase. | Lipoamide dehydrogenase, E3 component is part of three enzyme complexes. | 0.914 |
VF_A0497 | gcvP | VF_A0497 | VF_A0703 | L-allo-threonine aldolase. | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.945 |
VF_A0497 | glyA | VF_A0497 | VF_0695 | L-allo-threonine aldolase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
VF_A0497 | kbl | VF_A0497 | VF_A0418 | L-allo-threonine aldolase. | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.915 |
fumB | gcvP | VF_1180 | VF_A0703 | Anaerobic class I fumarate hydratase (fumarase B); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.944 |
fumB | glyA | VF_1180 | VF_0695 | Anaerobic class I fumarate hydratase (fumarase B); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.471 |
gcvH | VF_2301 | VF_A0702 | VF_2301 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoamide dehydrogenase. | 0.951 |
gcvH | gcvP | VF_A0702 | VF_A0703 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | VF_A0702 | VF_A0700 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex. | 0.999 |
gcvH | glyA | VF_A0702 | VF_0695 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
gcvH | lpd | VF_A0702 | VF_2178 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoamide dehydrogenase, E3 component is part of three enzyme complexes. | 0.961 |
gcvH | purD | VF_A0702 | VF_2395 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase; Belongs to the GARS family. | 0.472 |
gcvH | purL | VF_A0702 | VF_0652 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.519 |
gcvP | VF_2301 | VF_A0703 | VF_2301 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Dihydrolipoamide dehydrogenase. | 0.946 |
gcvP | VF_A0497 | VF_A0703 | VF_A0497 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | L-allo-threonine aldolase. | 0.945 |
gcvP | fumB | VF_A0703 | VF_1180 | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Anaerobic class I fumarate hydratase (fumarase B); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.944 |