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topA protein (Janibacter sp. HTCC2649) - STRING interaction network
"topA" - DNA topoisomerase I in Janibacter sp. HTCC2649
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
topADNA topoisomerase I ; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (942 aa)    
Predicted Functional Partners:
JNB_05994
ATP-dependent DNA helicase (707 aa)
   
  0.945
JNB_03775
DNA polymerase (889 aa)
 
  0.924
recA
Recombinase A ; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (354 aa)
 
  0.906
JNB_09554
ATPase (379 aa)
 
  0.901
JNB_00995
Transfer protein Tra-like (1920 aa)
   
 
  0.879
JNB_03240
Cyanophycin synthetase (972 aa)
   
 
  0.842
rpoC
Transcriptase subunit beta’ ; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (1297 aa)
     
 
  0.822
guaA
Glutamine amidotransferase ; Catalyzes the synthesis of GMP from XMP (529 aa)
   
   
  0.817
JNB_07424
DNA helicase (1047 aa)
   
 
  0.807
JNB_07419
Putative DNA helicase (1103 aa)
   
 
  0.807
Your Current Organism:
Janibacter sp. HTCC2649
NCBI taxonomy Id: 313589
Other names: J. sp. HTCC2649, Janibacter, Janibacter HTCC2649, Janibacter sp. HTCC2649
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