node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAR11559.1 | EAR11561.1 | PI23P_00095 | PI23P_00105 | Tetrapyrrole methylase family protein; COG0313 Predicted methyltransferases. | COG0824 Predicted thioesterase. | 0.516 |
EAR11559.1 | dnaA | PI23P_00095 | PI23P_00100 | Tetrapyrrole methylase family protein; COG0313 Predicted methyltransferases. | Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.918 |
EAR11561.1 | EAR11559.1 | PI23P_00105 | PI23P_00095 | COG0824 Predicted thioesterase. | Tetrapyrrole methylase family protein; COG0313 Predicted methyltransferases. | 0.516 |
EAR11561.1 | EAR12636.1 | PI23P_00105 | PI23P_08420 | COG0824 Predicted thioesterase. | Amino acid adenylation; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.852 |
EAR11561.1 | dnaA | PI23P_00105 | PI23P_00100 | COG0824 Predicted thioesterase. | Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.611 |
EAR12476.1 | EAR13066.1 | PI23P_07620 | PI23P_10570 | SpoOJ regulator protein; COG1192 ATPases involved in chromosome partitioning. | Putative FtsK/SpoIIIE-like protein; COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins. | 0.528 |
EAR12476.1 | dnaA | PI23P_07620 | PI23P_00100 | SpoOJ regulator protein; COG1192 ATPases involved in chromosome partitioning. | Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.585 |
EAR12636.1 | EAR11561.1 | PI23P_08420 | PI23P_00105 | Amino acid adenylation; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | COG0824 Predicted thioesterase. | 0.852 |
EAR12636.1 | dnaA | PI23P_08420 | PI23P_00100 | Amino acid adenylation; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.643 |
EAR12636.1 | gyrB | PI23P_08420 | PI23P_01000 | Amino acid adenylation; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.423 |
EAR12663.1 | EAR12884.1 | PI23P_08555 | PI23P_09660 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.466 |
EAR12663.1 | EAR13066.1 | PI23P_08555 | PI23P_10570 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | Putative FtsK/SpoIIIE-like protein; COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins. | 0.427 |
EAR12663.1 | dnaA | PI23P_08555 | PI23P_00100 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.983 |
EAR12663.1 | gyrB | PI23P_08555 | PI23P_01000 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.729 |
EAR12663.1 | recF | PI23P_08555 | PI23P_11882 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | DNA replication and repair protein RecF, ABC family ATPase; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. | 0.860 |
EAR12884.1 | EAR12663.1 | PI23P_09660 | PI23P_08555 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.466 |
EAR12884.1 | dnaA | PI23P_09660 | PI23P_00100 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.810 |
EAR13066.1 | EAR12476.1 | PI23P_10570 | PI23P_07620 | Putative FtsK/SpoIIIE-like protein; COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins. | SpoOJ regulator protein; COG1192 ATPases involved in chromosome partitioning. | 0.528 |
EAR13066.1 | EAR12663.1 | PI23P_10570 | PI23P_08555 | Putative FtsK/SpoIIIE-like protein; COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.427 |
EAR13066.1 | dnaA | PI23P_10570 | PI23P_00100 | Putative FtsK/SpoIIIE-like protein; COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins. | Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.539 |