node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ELI_04785 | ELI_10060 | ELI_04785 | ELI_10060 | 5-aminolevulinic acid synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain. | 0.912 |
ELI_04785 | ELI_10075 | ELI_04785 | ELI_10075 | 5-aminolevulinic acid synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | COG0404 Glycine cleavage system T protein (aminomethyltransferase). | 0.425 |
ELI_04785 | ELI_13610 | ELI_04785 | ELI_13610 | 5-aminolevulinic acid synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | COG2008 Threonine aldolase. | 0.909 |
ELI_04785 | gcvPA | ELI_04785 | ELI_10065 | 5-aminolevulinic acid synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.911 |
ELI_04785 | glyA | ELI_04785 | ELI_05650 | 5-aminolevulinic acid synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |
ELI_06145 | ELI_08010 | ELI_06145 | ELI_08010 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.915 |
ELI_06145 | ELI_10060 | ELI_06145 | ELI_10060 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain. | 0.925 |
ELI_06145 | ELI_10075 | ELI_06145 | ELI_10075 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG0404 Glycine cleavage system T protein (aminomethyltransferase). | 0.947 |
ELI_06145 | ELI_12125 | ELI_06145 | ELI_12125 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG0067 Glutamate synthase domain 1. | 0.876 |
ELI_06145 | gcvH | ELI_06145 | ELI_10070 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.956 |
ELI_06145 | gcvPA | ELI_06145 | ELI_10065 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.926 |
ELI_06145 | glyA | ELI_06145 | ELI_05650 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.913 |
ELI_06145 | purQ | ELI_06145 | ELI_02440 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.806 |
ELI_08010 | ELI_06145 | ELI_08010 | ELI_06145 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | 0.915 |
ELI_08010 | ELI_10060 | ELI_08010 | ELI_10060 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain. | 0.929 |
ELI_08010 | ELI_10075 | ELI_08010 | ELI_10075 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG0404 Glycine cleavage system T protein (aminomethyltransferase). | 0.953 |
ELI_08010 | ELI_12125 | ELI_08010 | ELI_12125 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | COG0067 Glutamate synthase domain 1. | 0.876 |
ELI_08010 | gcvH | ELI_08010 | ELI_10070 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.962 |
ELI_08010 | gcvPA | ELI_08010 | ELI_10065 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.928 |
ELI_08010 | glyA | ELI_08010 | ELI_05650 | COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.913 |