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fpg protein (Pelagibaca bermudensis) - STRING interaction network
"fpg" - DNA-(apurinic or apyrimidinic site) lyase MutM in Pelagibaca bermudensis
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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fpgDNA-(apurinic or apyrimidinic site) lyase MutM ; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3’- and 5’-phosphates (283 aa)    
Predicted Functional Partners:
coaE
Dephosphocoenzyme A kinase ; Catalyzes the phosphorylation of the 3’-hydroxyl group of dephosphocoenzyme A to form coenzyme A (196 aa)
   
  0.896
rpoH
RNA polymerase sigma-32 factor (298 aa)
 
   
  0.849
mutS
DNA mismatch repair protein MutS ; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (874 aa)
   
 
  0.848
R2601_15447
DNA polymerase I (935 aa)
 
   
  0.848
mfd
Transcription-repair-coupling factor ; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site (1158 aa)
   
     
  0.839
ruvC
Holliday junction resolvase RuvC ; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5’-terminal phosphate and a 3’-terminal hydroxyl group (163 aa)
       
 
  0.839
mutL
DNA mismatch repair protein MutL ; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (621 aa)
   
   
  0.834
uvrC
Excinuclease ABC subunit C ; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5’ and 3’ sides of the lesion. The N-terminal half is responsible for the 3’ incision and the C-terminal half is responsible for the 5’ incision (626 aa)
       
 
  0.830
rnd
Ribonuclease D ; Exonuclease involved in the 3’ processing of various precursor tRNAs. Initiates hydrolysis at the 3’-terminus of an RNA molecule and releases 5’-mononucleotides (385 aa)
   
   
  0.826
recA
Protein RecA ; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (213 aa)
         
  0.823
Your Current Organism:
Pelagibaca bermudensis
NCBI taxonomy Id: 314265
Other names: P. bermudensis HTCC2601, Pelagibaca, Pelagibaca Cho and Giovannoni 2006, Pelagibaca bermudensis, Pelagibaca bermudensis Cho and Giovannoni 2006, Pelagibaca bermudensis HTCC2601, Pelagibaca bermudensis str. HTCC2601, Pelagibaca bermudensis strain HTCC2601, Roseovarius sp. HTCC2601
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