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RB2654_05942 protein (Maritimibacter alkaliphilus) - STRING interaction network
"RB2654_05942" - Dihydrofolate reductase in Maritimibacter alkaliphilus
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RB2654_05942Dihydrofolate reductase ; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (159 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase ; Provides the sole de novo source of dTMP for DNA biosynthesis (272 aa)
 
  0.999
RB2654_11523
FolC bifunctional protein (423 aa)
   
  0.990
gcvP
Glycine dehydrogenase (aminomethyl-transferring) ; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (953 aa)
       
  0.913
glyA
Serine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (430 aa)
   
  0.902
fhs
Formyltetrahydrofolate synthetase (558 aa)
   
 
  0.866
fmt
Methionyl-tRNA formyltransferase ; Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by- (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (299 aa)
   
 
  0.862
RB2654_18583
Aminomethyltransferase ; The glycine cleavage system catalyzes the degradation of glycine (364 aa)
   
 
  0.857
purH
Bifunctional purine biosynthesis protein PurH (529 aa)
     
    0.853
RB2654_20213
Methionine synthase, 5-methyltetrahydrofolate--homocysteinemethyltransferase (349 aa)
       
  0.838
RB2654_02050
Methionine synthase I (338 aa)
       
  0.838
Your Current Organism:
Maritimibacter alkaliphilus
NCBI taxonomy Id: 314271
Other names: M. alkaliphilus, M. alkaliphilus HTCC2654, Maritimibacter, Maritimibacter Lee et al. 2007, Maritimibacter alkaliphilus, Maritimibacter alkaliphilus HTCC2654, Maritimibacter alkaliphilus Lee et al. 2007, Maritimibacter alkaliphilus str. HTCC2654, Maritimibacter alkaliphilus strain HTCC2654, Rhodobacterales bacterium HTCC2654
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