STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mecASimilar to MecA, putative adapter protein for Clp protease; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. (229 aa)    
Predicted Functional Partners:
LCA_1447
5 Proteins of unknown function that are similar to other proteins.
 
     0.863
spxA
Transcriptional regulator Spx; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily.
  
  
 0.766
rpoE
DNA-directed RNA polymerase, delta subunit; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.
  
     0.685
LCA_1446
5 Proteins of unknown function that are similar to other proteins.
  
  
 0.676
LCA_0630
Putative drug ABC exporter, membrane-spanning/permease subunit.
  
     0.673
LCA_1609
5 Proteins of unknown function that are similar to other proteins.
  
     0.652
LCA_0343
Hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.
  
     0.638
pbp2A
Bifunctional glycolsyltransferase/transpeptidase penicillin binding protein 2A.
  
   
 0.617
clpL
ATPase/chaperone ClpL, putative specificity factor for ClpP protease; Belongs to the ClpA/ClpB family.
    
 
 0.608
clpB
Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
    
 
 0.608
Your Current Organism:
Lactobacillus sakei
NCBI taxonomy Id: 314315
Other names: L. sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei str. 23K, Lactobacillus sakei subsp. sakei strain 23K
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