acsA protein (beta proteobacterium KB13) - STRING interaction network

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acsA

acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (657 aa)

Predicted Functional Partners:

KB13_1037

0.762

KB13_407

0.762

KB13_43

0.760

dhaL

0.757

prpB

0.717

oadA

0.705

KB13_885

0.678

KB13_804

0.652

prpC

0.644

gltA

0.644

Your Current Organism:

beta proteobacterium KB13

NCBI taxonomy Id: 314607
Other names: b. proteobacterium KB13

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KB13_1037	KB13_407	KB13_1037	KB13_407	Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	Peptidase U62, modulator of DNA gyrase; [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs.	0.792
KB13_1037	acsA	KB13_1037	KB13_356	Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.762
KB13_407	KB13_1037	KB13_407	KB13_1037	Peptidase U62, modulator of DNA gyrase; [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs.	Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.792
KB13_407	acsA	KB13_407	KB13_356	Peptidase U62, modulator of DNA gyrase; [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs.	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.762
KB13_43	acsA	KB13_43	KB13_356	[S] COG3564 Uncharacterized protein conserved in bacteria.	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.760
KB13_43	dhaL	KB13_43	KB13_677	[S] COG3564 Uncharacterized protein conserved in bacteria.	[C] COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family.	0.784
KB13_804	KB13_885	KB13_804	KB13_885	CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3- dehydrase reductase; [C] COG0633 Ferredoxin.	long-chain-fatty-acid--CoA ligase, putative; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	0.652
KB13_804	acsA	KB13_804	KB13_356	CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3- dehydrase reductase; [C] COG0633 Ferredoxin.	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.652
KB13_804	dhaL	KB13_804	KB13_677	CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3- dehydrase reductase; [C] COG0633 Ferredoxin.	[C] COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family.	0.768
KB13_804	oadA	KB13_804	KB13_124	CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3- dehydrase reductase; [C] COG0633 Ferredoxin.	[I] COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit.	0.669
KB13_885	KB13_804	KB13_885	KB13_804	long-chain-fatty-acid--CoA ligase, putative; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3- dehydrase reductase; [C] COG0633 Ferredoxin.	0.652
KB13_885	acsA	KB13_885	KB13_356	long-chain-fatty-acid--CoA ligase, putative; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.678
KB13_885	dhaL	KB13_885	KB13_677	long-chain-fatty-acid--CoA ligase, putative; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	[C] COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family.	0.757
KB13_885	gltA	KB13_885	KB13_992	long-chain-fatty-acid--CoA ligase, putative; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	[C] COG0372 Citrate synthase; Belongs to the citrate synthase family.	0.644
KB13_885	oadA	KB13_885	KB13_124	long-chain-fatty-acid--CoA ligase, putative; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	[I] COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit.	0.705
KB13_885	prpB	KB13_885	KB13_1	long-chain-fatty-acid--CoA ligase, putative; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.	0.778
KB13_885	prpC	KB13_885	KB13_95	long-chain-fatty-acid--CoA ligase, putative; [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.	[C] COG0372 Citrate synthase; Belongs to the citrate synthase family.	0.718
acsA	KB13_1037	KB13_356	KB13_1037	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.762
acsA	KB13_407	KB13_356	KB13_407	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	Peptidase U62, modulator of DNA gyrase; [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs.	0.762
acsA	KB13_43	KB13_356	KB13_43	acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	[S] COG3564 Uncharacterized protein conserved in bacteria.	0.760

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