node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPE_0872 | RPE_2240 | RPE_0872 | RPE_2240 | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | 0.891 |
RPE_0872 | hisA | RPE_0872 | RPE_0367 | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: rpc:RPC_0307 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.940 |
RPE_0872 | hisB | RPE_0872 | RPE_0370 | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: nha:Nham_0122 imidazoleglycerol-phosphate dehydratase. | 0.942 |
RPE_0872 | hisD | RPE_0872 | RPE_4484 | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.941 |
RPE_0872 | hisE | RPE_0872 | RPE_0365 | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_0311 phosphoribosyl-ATP pyrophosphohydrolase. | 0.988 |
RPE_0872 | hisE-2 | RPE_0872 | RPE_0754 | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_0716 phosphoribosyl-ATP pyrophosphohydrolase. | 0.988 |
RPE_0872 | hisF | RPE_0872 | RPE_0366 | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.941 |
RPE_0872 | hisG | RPE_0872 | RPE_0871 | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | ATP phosphoribosyltransferase (homohexameric) / ATP phosphoribosyltransferase regulatory subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
RPE_0872 | hisH | RPE_0872 | RPE_0368 | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.935 |
RPE_0872 | hisI | RPE_0872 | RPE_2349 | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.944 |
RPE_2240 | RPE_0872 | RPE_2240 | RPE_0872 | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase, class II (G, H, P and S); KEGG: rpb:RPB_1846 tRNA synthetase, class II (G, H, P and S). | 0.891 |
RPE_2240 | hisA | RPE_2240 | RPE_0367 | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: rpc:RPC_0307 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.924 |
RPE_2240 | hisB | RPE_2240 | RPE_0370 | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: nha:Nham_0122 imidazoleglycerol-phosphate dehydratase. | 0.925 |
RPE_2240 | hisD | RPE_2240 | RPE_4484 | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.927 |
RPE_2240 | hisE | RPE_2240 | RPE_0365 | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_0311 phosphoribosyl-ATP pyrophosphohydrolase. | 0.871 |
RPE_2240 | hisE-2 | RPE_2240 | RPE_0754 | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rpc:RPC_0716 phosphoribosyl-ATP pyrophosphohydrolase. | 0.869 |
RPE_2240 | hisF | RPE_2240 | RPE_0366 | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.923 |
RPE_2240 | hisG | RPE_2240 | RPE_0871 | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | ATP phosphoribosyltransferase (homohexameric) / ATP phosphoribosyltransferase regulatory subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.908 |
RPE_2240 | hisH | RPE_2240 | RPE_0368 | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.926 |
RPE_2240 | hisI | RPE_2240 | RPE_2349 | PFAM: aminotransferase, class I and II; KEGG: rpc:RPC_3743 aminotransferase, class I and II. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.926 |