node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPE_0002 | RPE_0560 | RPE_0002 | RPE_0560 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: SNF2-related protein; helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; KEGG: xcb:XC_0536 helicase. | 0.946 |
RPE_0002 | RPE_1250 | RPE_0002 | RPE_1250 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: metallophosphoesterase; KEGG: rpc:RPC_1185 metallophosphoesterase. | 0.643 |
RPE_0002 | RPE_2164 | RPE_0002 | RPE_2164 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: SNF2-related protein; helicase domain protein; SMART: DEAD/DEAH box helicase domain protein; KEGG: noc:Noc_0063 type III restriction enzyme, res subunit. | 0.946 |
RPE_0002 | RPE_4912 | RPE_0002 | RPE_4912 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; KEGG: rpd:RPD_4412 ATP-dependent DNA helicase RecQ. | 0.854 |
RPE_0002 | lexA | RPE_0002 | RPE_2571 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.511 |
RPE_0002 | polA | RPE_0002 | RPE_4821 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.997 |
RPE_0002 | recA | RPE_0002 | RPE_1594 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.929 |
RPE_0002 | topA | RPE_0002 | RPE_3379 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.766 |
RPE_0560 | RPE_0002 | RPE_0560 | RPE_0002 | PFAM: SNF2-related protein; helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; KEGG: xcb:XC_0536 helicase. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.946 |
RPE_0560 | RPE_1250 | RPE_0560 | RPE_1250 | PFAM: SNF2-related protein; helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; KEGG: xcb:XC_0536 helicase. | PFAM: metallophosphoesterase; KEGG: rpc:RPC_1185 metallophosphoesterase. | 0.622 |
RPE_0560 | RPE_4912 | RPE_0560 | RPE_4912 | PFAM: SNF2-related protein; helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; KEGG: xcb:XC_0536 helicase. | TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; KEGG: rpd:RPD_4412 ATP-dependent DNA helicase RecQ. | 0.857 |
RPE_0560 | polA | RPE_0560 | RPE_4821 | PFAM: SNF2-related protein; helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; KEGG: xcb:XC_0536 helicase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.953 |
RPE_0560 | recA | RPE_0560 | RPE_1594 | PFAM: SNF2-related protein; helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; KEGG: xcb:XC_0536 helicase. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.895 |
RPE_0560 | topA | RPE_0560 | RPE_3379 | PFAM: SNF2-related protein; helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; KEGG: xcb:XC_0536 helicase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.725 |
RPE_1250 | RPE_0002 | RPE_1250 | RPE_0002 | PFAM: metallophosphoesterase; KEGG: rpc:RPC_1185 metallophosphoesterase. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.643 |
RPE_1250 | RPE_0560 | RPE_1250 | RPE_0560 | PFAM: metallophosphoesterase; KEGG: rpc:RPC_1185 metallophosphoesterase. | PFAM: SNF2-related protein; helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; KEGG: xcb:XC_0536 helicase. | 0.622 |
RPE_1250 | RPE_2119 | RPE_1250 | RPE_2119 | PFAM: metallophosphoesterase; KEGG: rpc:RPC_1185 metallophosphoesterase. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.510 |
RPE_1250 | RPE_2164 | RPE_1250 | RPE_2164 | PFAM: metallophosphoesterase; KEGG: rpc:RPC_1185 metallophosphoesterase. | PFAM: SNF2-related protein; helicase domain protein; SMART: DEAD/DEAH box helicase domain protein; KEGG: noc:Noc_0063 type III restriction enzyme, res subunit. | 0.622 |
RPE_1250 | RPE_4912 | RPE_1250 | RPE_4912 | PFAM: metallophosphoesterase; KEGG: rpc:RPC_1185 metallophosphoesterase. | TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; KEGG: rpd:RPD_4412 ATP-dependent DNA helicase RecQ. | 0.975 |
RPE_1250 | polA | RPE_1250 | RPE_4821 | PFAM: metallophosphoesterase; KEGG: rpc:RPC_1185 metallophosphoesterase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.983 |