node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPE_0290 | RPE_0897 | RPE_0290 | RPE_0897 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: rpc:RPC_0183 dihydrolipoamide dehydrogenase. | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | 0.905 |
RPE_0290 | RPE_1597 | RPE_0290 | RPE_1597 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: rpc:RPC_0183 dihydrolipoamide dehydrogenase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: rpd:RPD_1733 glycine cleavage system T protein. | 0.966 |
RPE_0290 | RPE_2618 | RPE_0290 | RPE_2618 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: rpc:RPC_0183 dihydrolipoamide dehydrogenase. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: rpd:RPD_2807 dihydrolipoamide dehydrogenase. | 0.911 |
RPE_0290 | gcvH | RPE_0290 | RPE_1596 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: rpc:RPC_0183 dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.989 |
RPE_0290 | gcvP | RPE_0290 | RPE_1595 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: rpc:RPC_0183 dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.958 |
RPE_0290 | glyA | RPE_0290 | RPE_2808 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: rpc:RPC_0183 dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
RPE_0897 | RPE_0290 | RPE_0897 | RPE_0290 | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: rpc:RPC_0183 dihydrolipoamide dehydrogenase. | 0.905 |
RPE_0897 | RPE_1359 | RPE_0897 | RPE_1359 | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | 0.918 |
RPE_0897 | RPE_1597 | RPE_0897 | RPE_1597 | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: rpd:RPD_1733 glycine cleavage system T protein. | 0.946 |
RPE_0897 | RPE_1630 | RPE_0897 | RPE_1630 | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: bja:blr5707 putative threonine aldolase. | 0.931 |
RPE_0897 | RPE_2618 | RPE_0897 | RPE_2618 | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: rpd:RPD_2807 dihydrolipoamide dehydrogenase. | 0.905 |
RPE_0897 | gcvH | RPE_0897 | RPE_1596 | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.924 |
RPE_0897 | gcvP | RPE_0897 | RPE_1595 | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.953 |
RPE_0897 | glyA | RPE_0897 | RPE_2808 | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
RPE_0897 | purD | RPE_0897 | RPE_4612 | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | KEGG: rpc:RPC_4619 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. | 0.813 |
RPE_1359 | RPE_0897 | RPE_1359 | RPE_0897 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | PFAM: aminotransferase, class V; KEGG: rpc:RPC_4689 aminotransferase, class V. | 0.918 |
RPE_1359 | RPE_1597 | RPE_1359 | RPE_1597 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: rpd:RPD_1733 glycine cleavage system T protein. | 0.569 |
RPE_1359 | RPE_1630 | RPE_1359 | RPE_1630 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: bja:blr5707 putative threonine aldolase. | 0.919 |
RPE_1359 | gcvH | RPE_1359 | RPE_1596 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.416 |
RPE_1359 | gcvP | RPE_1359 | RPE_1595 | KEGG: rpc:RPC_1325 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; aminotransferase class-III. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.947 |