node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPE_1070 | RPE_2149 | RPE_1070 | RPE_2149 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpc:RPC_1152 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | 0.905 |
RPE_1070 | dut | RPE_1070 | RPE_0466 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpc:RPC_1152 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.901 |
RPE_1070 | surE | RPE_1070 | RPE_2703 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpc:RPC_1152 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.919 |
RPE_1070 | thyA | RPE_1070 | RPE_2150 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpc:RPC_1152 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.905 |
RPE_1070 | tmk | RPE_1070 | RPE_2865 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpc:RPC_1152 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.933 |
RPE_1597 | RPE_2149 | RPE_1597 | RPE_2149 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: rpd:RPD_1733 glycine cleavage system T protein. | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | 0.921 |
RPE_1597 | RPE_2177 | RPE_1597 | RPE_2177 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: rpd:RPD_1733 glycine cleavage system T protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.923 |
RPE_1597 | RPE_3772 | RPE_1597 | RPE_3772 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: rpd:RPD_1733 glycine cleavage system T protein. | KEGG: rpb:RPB_1765 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.940 |
RPE_1597 | folD | RPE_1597 | RPE_0047 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: rpd:RPD_1733 glycine cleavage system T protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.971 |
RPE_1597 | glyA | RPE_1597 | RPE_2808 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: rpd:RPD_1733 glycine cleavage system T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
RPE_1597 | thyA | RPE_1597 | RPE_2150 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: rpd:RPD_1733 glycine cleavage system T protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.921 |
RPE_2149 | RPE_1070 | RPE_2149 | RPE_1070 | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: rpc:RPC_1152 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | 0.905 |
RPE_2149 | RPE_1597 | RPE_2149 | RPE_1597 | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: rpd:RPD_1733 glycine cleavage system T protein. | 0.921 |
RPE_2149 | RPE_2177 | RPE_2149 | RPE_2177 | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.995 |
RPE_2149 | RPE_3772 | RPE_2149 | RPE_3772 | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | KEGG: rpb:RPB_1765 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.921 |
RPE_2149 | dut | RPE_2149 | RPE_0466 | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.965 |
RPE_2149 | folD | RPE_2149 | RPE_0047 | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.940 |
RPE_2149 | glyA | RPE_2149 | RPE_2808 | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
RPE_2149 | surE | RPE_2149 | RPE_2703 | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.913 |
RPE_2149 | thyA | RPE_2149 | RPE_2150 | PFAM: thymidylate synthase; KEGG: rpc:RPC_3266 thymidylate synthase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.951 |