node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPE_0019 | RPE_1954 | RPE_0019 | RPE_1954 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | KEGG: rpd:RPD_2023 2-dehydropantoate 2-reductase; TIGRFAM: 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE, N-terminal domain protein; Ketopantoate reductase ApbA/PanE, C-terminal domain protein. | 0.928 |
RPE_0019 | panB | RPE_0019 | RPE_3348 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.929 |
RPE_0019 | panC | RPE_0019 | RPE_3413 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.929 |
RPE_0467 | cmk | RPE_0467 | RPE_0446 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | KEGG: rpc:RPC_0398 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. | 0.427 |
RPE_0467 | coaA | RPE_0467 | RPE_0364 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | KEGG: rpc:RPC_0312 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | 0.924 |
RPE_0467 | panB | RPE_0467 | RPE_3348 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.520 |
RPE_0467 | panC | RPE_0467 | RPE_3413 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.899 |
RPE_0915 | RPE_2260 | RPE_0915 | RPE_2260 | PFAM: aminotransferase class-III; KEGG: rpc:RPC_0894 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | PFAM: aldehyde dehydrogenase; KEGG: rpd:RPD_2215 aldehyde dehydrogenase. | 0.909 |
RPE_0915 | panC | RPE_0915 | RPE_3413 | PFAM: aminotransferase class-III; KEGG: rpc:RPC_0894 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.923 |
RPE_1954 | RPE_0019 | RPE_1954 | RPE_0019 | KEGG: rpd:RPD_2023 2-dehydropantoate 2-reductase; TIGRFAM: 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE, N-terminal domain protein; Ketopantoate reductase ApbA/PanE, C-terminal domain protein. | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.928 |
RPE_1954 | panB | RPE_1954 | RPE_3348 | KEGG: rpd:RPD_2023 2-dehydropantoate 2-reductase; TIGRFAM: 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE, N-terminal domain protein; Ketopantoate reductase ApbA/PanE, C-terminal domain protein. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.929 |
RPE_1954 | panC | RPE_1954 | RPE_3413 | KEGG: rpd:RPD_2023 2-dehydropantoate 2-reductase; TIGRFAM: 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE, N-terminal domain protein; Ketopantoate reductase ApbA/PanE, C-terminal domain protein. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.929 |
RPE_2260 | RPE_0915 | RPE_2260 | RPE_0915 | PFAM: aldehyde dehydrogenase; KEGG: rpd:RPD_2215 aldehyde dehydrogenase. | PFAM: aminotransferase class-III; KEGG: rpc:RPC_0894 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.909 |
RPE_2260 | panC | RPE_2260 | RPE_3413 | PFAM: aldehyde dehydrogenase; KEGG: rpd:RPD_2215 aldehyde dehydrogenase. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.902 |
RPE_2756 | panC | RPE_2756 | RPE_3413 | Putative TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.701 |
cmk | RPE_0467 | RPE_0446 | RPE_0467 | KEGG: rpc:RPC_0398 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.427 |
cmk | panC | RPE_0446 | RPE_3413 | KEGG: rpc:RPC_0398 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.912 |
coaA | RPE_0467 | RPE_0364 | RPE_0467 | KEGG: rpc:RPC_0312 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.924 |
coaA | panC | RPE_0364 | RPE_3413 | KEGG: rpc:RPC_0312 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.921 |
dusA | panC | RPE_1976 | RPE_3413 | TIM-barrel protein, yjbN family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.701 |