node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAK27910.1 | hisA | SynRCC307_1007 | SynRCC307_1010 | Uncharacterized conserved secreted protein. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | 0.759 |
CAK29251.1 | hisA | SynRCC307_2348 | SynRCC307_1010 | Histidinol-phosphate/aromatic aminotransferase related enzyme; Amino acid transport and metabolism. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | 0.828 |
CAK29251.1 | hisB | SynRCC307_2348 | SynRCC307_2290 | Histidinol-phosphate/aromatic aminotransferase related enzyme; Amino acid transport and metabolism. | Imidazoleglycerol-phosphate dehydratase; Amino acid transport and metabolism. | 0.862 |
CAK29251.1 | hisD | SynRCC307_2348 | SynRCC307_1962 | Histidinol-phosphate/aromatic aminotransferase related enzyme; Amino acid transport and metabolism. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.874 |
CAK29251.1 | hisF | SynRCC307_2348 | SynRCC307_0579 | Histidinol-phosphate/aromatic aminotransferase related enzyme; Amino acid transport and metabolism. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.865 |
CAK29251.1 | hisG | SynRCC307_2348 | SynRCC307_0838 | Histidinol-phosphate/aromatic aminotransferase related enzyme; Amino acid transport and metabolism. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.822 |
CAK29251.1 | hisH | SynRCC307_2348 | SynRCC307_0736 | Histidinol-phosphate/aromatic aminotransferase related enzyme; Amino acid transport and metabolism. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.889 |
CAK29251.1 | hisIE | SynRCC307_2348 | SynRCC307_1619 | Histidinol-phosphate/aromatic aminotransferase related enzyme; Amino acid transport and metabolism. | Histidine biosynthesis bifunctional protein HisIE; Amino acid transport and metabolism; In the N-terminal section; belongs to the PRA-CH family. | 0.997 |
guaA | hisA | SynRCC307_0049 | SynRCC307_1010 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | 0.790 |
guaA | hisF | SynRCC307_0049 | SynRCC307_0579 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.514 |
guaA | hisH | SynRCC307_0049 | SynRCC307_0736 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.535 |
hisA | CAK27910.1 | SynRCC307_1010 | SynRCC307_1007 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | Uncharacterized conserved secreted protein. | 0.759 |
hisA | CAK29251.1 | SynRCC307_1010 | SynRCC307_2348 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | Histidinol-phosphate/aromatic aminotransferase related enzyme; Amino acid transport and metabolism. | 0.828 |
hisA | guaA | SynRCC307_1010 | SynRCC307_0049 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.790 |
hisA | hisB | SynRCC307_1010 | SynRCC307_2290 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | Imidazoleglycerol-phosphate dehydratase; Amino acid transport and metabolism. | 0.987 |
hisA | hisC | SynRCC307_1010 | SynRCC307_2242 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | Histidinol-phosphate aminotransferase; Amino acid transport and metabolism. | 0.842 |
hisA | hisD | SynRCC307_1010 | SynRCC307_1962 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.989 |
hisA | hisF | SynRCC307_1010 | SynRCC307_0579 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.996 |
hisA | hisG | SynRCC307_1010 | SynRCC307_0838 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.983 |
hisA | hisH | SynRCC307_1010 | SynRCC307_0736 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Amino acid transport and metabolism. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |