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ftsA protein (Escherichia coli K12 DH10B) - STRING interaction network
"ftsA" - Cell division protein FtsA in Escherichia coli K12 DH10B
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ftsACell division protein FtsA; Essential cell division protein that assists in the assembly of the Z ring (PubMed-11847116). May serve as the principal membrane anchor for the Z ring (PubMed-15752196). Also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL, FtsI and FtsN (PubMed-9282742, PubMed-9495771, PubMed-9603865, PubMed-9882666, PubMed-10027987, PubMed-24750258). Binds ATP (PubMed-11053380) (420 aa)    
Predicted Functional Partners:
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. Polymerization and bundle formation is enhanced by CbeA (383 aa)
 
 
  0.999
ftsQ
Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (276 aa)
   
 
  0.998
ftsI
Transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3); Essential cell division protein that is required for the synthesis of peptidoglycan at the division septum (PubMed-1103132, PubMed-9614966). Catalyzes the synthesis of cross-linked peptidoglycan from the lipid-linked precursors (PubMed-7030331). Required for localization of FtsN (PubMed-9282742) (588 aa)
 
 
  0.995
ftsW
Cell division protein FtsW; Essential cell division protein. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. Required for localization of FtsI. May play a role in the stabilization of the FtsZ ring during cell division (414 aa)
 
 
  0.977
zipA
Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring (PubMed-9008158, PubMed-11847116, PubMed-22164258, PubMed-22304478, PubMed-23233671). Also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL and FtsN (PubMed-11847116, PubMed-11948172). ZipA overproduction protects FtsZ from degradation by ClpP by preventing recognition by ClpX (PubMed-23233671). Does not affect the GTPase activity of FtsZ (PubMed- [...] (328 aa)
     
 
  0.969
murC
UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation (491 aa)
   
   
  0.962
murG
Undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (355 aa)
 
   
  0.957
mreB
Rod shape-determining protein MreB; Involved in formation of the rod shape of the cell. May act as a negative regulator of FtsI. Polymerization and bundle formation is enhanced by CbeA (347 aa)
 
 
  0.953
ddlB
D-alanine--D-alanine ligase; Cell wall formation (306 aa)
   
 
  0.947
ftsN
Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases (Probable) (PubMed-25496160). Required for full FtsI activity (PubMed-25496160). Required for recruitment of AmiC to the septal ring (PubMed-12787347) (319 aa)
       
 
  0.944
Your Current Organism:
Escherichia coli K12 DH10B
NCBI taxonomy Id: 316385
Other names: E. coli str. K-12 substr. DH10B, Escherichia coli DH10B, Escherichia coli K12 DH10B, Escherichia coli str. K-12 substr. DH10B, Escherichia coli str. K12 substr. DH10B, Escherichia coli strain K12 substrain DH10B
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