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ybcL protein (Escherichia coli K12 DH10B) - STRING interaction network
"ybcL" - Putative kinase inhibitor in Escherichia coli K12 DH10B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ybcLPutative kinase inhibitor (183 aa)    
Predicted Functional Partners:
rplQ
50S ribosomal protein L17; Requires L15 for assembly into the 50S subunit (127 aa)
     
    0.957
rpmA
50S ribosomal protein L27 (85 aa)
     
    0.943
rplS
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface. In the 70S ribosome it has been modeled to make two contacts with the 16S rRNA of the 30S subunit forming part of bridges B6 and B8 (PubMed-12809609). In the 3.5 A resolved structures L14 and L19 interact and together make contact with the 16S rRNA (PubMed-16272117). The protein conformation is quite different between the 50S and 70S structures, which may be necessary for translocation (115 aa)
     
    0.937
rplD
50S ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5’-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (201 aa)
     
    0.930
rpmF
50S ribosomal protein L32 (57 aa)
     
    0.926
rplO
50S ribosomal protein L15; This protein binds the 5S rRNA. It is required for the late stages of subunit assembly, and is essential for 5S rRNA assembly onto the ribosome (144 aa)
     
    0.912
rplP
50S ribosomal protein L16; This protein binds directly to 23S ribosomal RNA and is located at the A site of the peptidyltransferase center. It contacts the A and P site tRNAs. It has an essential role in subunit assembly, which is not well understood (136 aa)
     
    0.907
rplC
50S ribosomal protein L3; One of two assembly initiator proteins, it binds directly near the 3’-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (209 aa)
     
    0.907
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (142 aa)
   
    0.904
ybcM
DLP12 prophage; DNA-binding transcriptional regulator (265 aa)
 
          0.893
Your Current Organism:
Escherichia coli K12 DH10B
NCBI taxonomy Id: 316385
Other names: E. coli str. K-12 substr. DH10B, Escherichia coli DH10B, Escherichia coli K12 DH10B, Escherichia coli str. K-12 substr. DH10B, Escherichia coli str. K12 substr. DH10B, Escherichia coli strain K12 substrain DH10B
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