STRINGSTRING
ggt protein (Escherichia coli K12 DH10B) - STRING interaction network
"ggt" - Gamma-glutamyltranspeptidase in Escherichia coli K12 DH10B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ggtGamma-glutamyltranspeptidase (580 aa)    
Predicted Functional Partners:
gshB
Glutathione synthetase (316 aa)
         
  0.970
gltB
Glutamate synthase subunit alpha (1517 aa)
       
    0.795
putA
Trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon (1320 aa)
   
 
  0.790
glnA
Glutamine synthetase (469 aa)
     
 
  0.749
btuE
Putative glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent. In vitro, utilizes preferentially thioredoxin A to decompose hydrogen peroxide as well as cumene-, tert-butyl-, and linoleic acid hydroperoxides, suggesting that it may have one or more organic hydroperoxide as its physiological substrate (183 aa)
     
 
  0.742
gor
Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol (450 aa)
     
 
  0.728
yfcF
Hypothetical protein; Exhibits glutathione (GSH) S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB); however this activity is as low as 1% of that of GstA. Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide. Is involved in defense against oxidative stress, probably via its peroxidase activity (214 aa)
   
 
  0.727
gshA
Glutamate--cysteine ligase (518 aa)
       
  0.719
gss
Bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Catalyzes the formation of an amide bond between glutathione (GSH) and spermidine coupled with hydrolysis of ATP; also catalyzes the opposing reaction, i.e. the hydrolysis of glutathionylspermidine (Gsp) back to glutathione and spermidine. The amidase active site can also hydrolyze Gsp-disulfide (Gsp-S-S- Gsp) to Gsp-SG and Gsp S-thiolated proteins (GspSSPs) to GSH S- thiolated protein (GSSPs). Likely acts synergistically with glutaredoxin to regulate the redox environment of E.coli and defend against oxidat [...] (619 aa)
   
   
    0.714
glsA2
Glutaminase (308 aa)
     
 
  0.714
Your Current Organism:
Escherichia coli K12 DH10B
NCBI taxonomy Id: 316385
Other names: E. coli str. K-12 substr. DH10B, Escherichia coli DH10B, Escherichia coli K12 DH10B, Escherichia coli str. K-12 substr. DH10B, Escherichia coli str. K12 substr. DH10B, Escherichia coli strain K12 substrain DH10B
Server load: low (10%) [HD]