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metB protein (Escherichia coli K12 DH10B) - STRING interaction network
"metB" - Cystathionine gamma-synthase in Escherichia coli K12 DH10B
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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metBCystathionine gamma-synthase; Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia (386 aa)    
Predicted Functional Partners:
metA
Homoserine O-succinyltransferase (309 aa)
 
 
  0.994
metL
Bifunctional aspartate kinase II/homoserine dehydrogenase II (810 aa)
   
  0.991
metC
Cystathionine beta-lyase (395 aa)
   
 
0.978
ydbK
Fused pyruvate-flavodoxin oxidoreductase- FeS binding protein; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (1174 aa)
   
  0.962
thrA
Bifunctional aspartokinase I/homoserine dehydrogenase I (820 aa)
   
  0.944
cysK
Cysteine synthase A; In addition to its role in cysteine synthesis, stimulates the tRNase activity of CdiA-CT from E.coli strain 536 / UPEC; stimulation does not require O-acetylserine sulfhydrylase activity. CdiA is the toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion (experiments done in strains BW25113 and X90, both K12 derivatives). This protein is not required [...] (323 aa)
 
  0.939
cysM
Cysteine synthase B; Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product (303 aa)
 
  0.935
metE
5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (753 aa)
   
 
  0.934
metF
5,10-methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine (296 aa)
   
  0.933
metH
B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (1227 aa)
   
 
  0.909
Your Current Organism:
Escherichia coli K12 DH10B
NCBI taxonomy Id: 316385
Other names: E. coli str. K-12 substr. DH10B, Escherichia coli DH10B, Escherichia coli K12 DH10B, Escherichia coli str. K-12 substr. DH10B, Escherichia coli str. K12 substr. DH10B, Escherichia coli strain K12 substrain DH10B
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