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chpS protein (Escherichia coli K12 DH10B) - STRING interaction network
"chpS" - Antitoxin ChpS in Escherichia coli K12 DH10B
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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chpSAntitoxin ChpS; Antitoxin component of a type II toxin-antitoxin (TA) module. May be involved in the regulation of cell growth. It acts as a suppressor of the endoribonuclease (inhibitory function) of ChpB protein. Both ChpS and ChpB probably bind to the promoter region of the chpS-chpB operon to autoregulate their synthesis (83 aa)    
Predicted Functional Partners:
chpB
Toxin ChpB; Toxic component of a type II toxin-antitoxin (TA) module. ChpB is a sequence-specific mRNA and (weak) tmRNA endoribonuclease that inhibits protein synthesis and induces bacterial stasis. Cleavage is independent of the ribosome. Cleavage occurs at ACY sequences where Y is not C. The endoribonuclease activity is not as strong as that of MazF. The endoribonuclease activity (a toxin) is inhibited by its labile cognate antitoxin ChpS. Toxicity results when the levels of ChpS decrease in the cell, leading to mRNA degradation. Both ChpS and ChpB probably bind to the promoter regio [...] (116 aa)
 
 
  0.979
mazF
Toxin ChpA; Toxic component of a type II toxin-antitoxin (TA) module. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and inducing bacterial stasis. It is stable, single-strand specific with mRNA cleavage independent of the ribosome, although translation enhances cleavage for some mRNAs (PubMed-18854355). Cleavage occurs at the 5’-end of ACA sequences, yielding a 2’,3’-cyclic phosphate and a free 5’-OH, although cleavage can also occur on the 3’-end of the first A (PubMed-15537630, PubMed-23280569). Digests 16S rRNA in vivo 43 nts upstream of the C-t [...] (111 aa)
 
 
  0.812
chpR
Antitoxin MazE; Antitoxin component of a type II toxin-antitoxin (TA) module. Labile antitoxin that binds to the MazF endoribonuclease toxin and neutralizes its endoribonuclease activity. Is considered to be an ’addiction’ molecule as the cell dies in its absence. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and [...] (82 aa)
   
          0.622
rcnA
Nickel/cobalt efflux protein RcnA; Efflux system for nickel and cobalt (274 aa)
   
          0.578
b4223
Hypothetical protein; Could be a multicopy suppressor of the ileR regulatory mutation (89 aa)
              0.552
yqeI
Transcriptional regulator (269 aa)
   
          0.529
gspL
General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (387 aa)
   
          0.487
yhhZ
Hypothetical protein (392 aa)
   
          0.475
lacI
Lac repressor; Repressor of the lactose operon. Binds allolactose as an inducer (360 aa)
   
          0.473
yidJ
Sulfatase/phosphatase (497 aa)
   
          0.446
Your Current Organism:
Escherichia coli K12 DH10B
NCBI taxonomy Id: 316385
Other names: E. coli str. K-12 substr. DH10B, Escherichia coli DH10B, Escherichia coli K12 DH10B, Escherichia coli str. K-12 substr. DH10B, Escherichia coli str. K12 substr. DH10B, Escherichia coli strain K12 substrain DH10B
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