node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tcr_0113 | Tcr_0154 | Tcr_0113 | Tcr_0154 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: vfi:VF0053 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.894 |
Tcr_0113 | cysG | Tcr_0113 | Tcr_1160 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.969 |
Tcr_0113 | hemA | Tcr_0113 | Tcr_0390 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.608 |
Tcr_0113 | hemC | Tcr_0113 | Tcr_0112 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
Tcr_0113 | hemE | Tcr_0113 | Tcr_0123 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.936 |
Tcr_0154 | Tcr_0113 | Tcr_0154 | Tcr_0113 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: vfi:VF0053 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.894 |
Tcr_0154 | cysG | Tcr_0154 | Tcr_1160 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: vfi:VF0053 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.932 |
Tcr_0154 | hemA | Tcr_0154 | Tcr_0390 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: vfi:VF0053 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.870 |
Tcr_0154 | hemC | Tcr_0154 | Tcr_0112 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: vfi:VF0053 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
Tcr_0154 | hemE | Tcr_0154 | Tcr_0123 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: vfi:VF0053 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.713 |
Tcr_1157 | Tcr_1158 | Tcr_1157 | Tcr_1158 | TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like nitrite and sulphite reductase 4Fe-4S region BFD-like [2Fe-2S]-binding region; KEGG: eca:ECA2991 nitrite reductase [NAD(P)H] large subunit. | KEGG: aci:ACIAD1909 putative nitrate reductase (electron transfer subunit) and putative nitrite reductase (small subunit). | 0.999 |
Tcr_1157 | Tcr_1159 | Tcr_1157 | Tcr_1159 | TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like nitrite and sulphite reductase 4Fe-4S region BFD-like [2Fe-2S]-binding region; KEGG: eca:ECA2991 nitrite reductase [NAD(P)H] large subunit. | Assimilatory nitrate reductase (NADH) alpha subunit apoprotein; PFAM: molybdopterin oxidoreductase molydopterin dinucleotide-binding region molybdopterin oxidoreductase Fe4S4 region BFD-like [2Fe-2S]-binding region; KEGG: nasA, RSp1219; probable nitrate reductase large subunit oxidoreductase protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.993 |
Tcr_1157 | Tcr_1488 | Tcr_1157 | Tcr_1488 | TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like nitrite and sulphite reductase 4Fe-4S region BFD-like [2Fe-2S]-binding region; KEGG: eca:ECA2991 nitrite reductase [NAD(P)H] large subunit. | Ketohexokinase; PFAM: Rieske [2Fe-2S] region PfkB; KEGG: hsa:3795 ketohexokinase (fructokinase). | 0.757 |
Tcr_1157 | cysG | Tcr_1157 | Tcr_1160 | TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like nitrite and sulphite reductase 4Fe-4S region BFD-like [2Fe-2S]-binding region; KEGG: eca:ECA2991 nitrite reductase [NAD(P)H] large subunit. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.849 |
Tcr_1158 | Tcr_1157 | Tcr_1158 | Tcr_1157 | KEGG: aci:ACIAD1909 putative nitrate reductase (electron transfer subunit) and putative nitrite reductase (small subunit). | TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like nitrite and sulphite reductase 4Fe-4S region BFD-like [2Fe-2S]-binding region; KEGG: eca:ECA2991 nitrite reductase [NAD(P)H] large subunit. | 0.999 |
Tcr_1158 | Tcr_1159 | Tcr_1158 | Tcr_1159 | KEGG: aci:ACIAD1909 putative nitrate reductase (electron transfer subunit) and putative nitrite reductase (small subunit). | Assimilatory nitrate reductase (NADH) alpha subunit apoprotein; PFAM: molybdopterin oxidoreductase molydopterin dinucleotide-binding region molybdopterin oxidoreductase Fe4S4 region BFD-like [2Fe-2S]-binding region; KEGG: nasA, RSp1219; probable nitrate reductase large subunit oxidoreductase protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | 0.992 |
Tcr_1158 | cysG | Tcr_1158 | Tcr_1160 | KEGG: aci:ACIAD1909 putative nitrate reductase (electron transfer subunit) and putative nitrite reductase (small subunit). | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.965 |
Tcr_1159 | Tcr_1157 | Tcr_1159 | Tcr_1157 | Assimilatory nitrate reductase (NADH) alpha subunit apoprotein; PFAM: molybdopterin oxidoreductase molydopterin dinucleotide-binding region molybdopterin oxidoreductase Fe4S4 region BFD-like [2Fe-2S]-binding region; KEGG: nasA, RSp1219; probable nitrate reductase large subunit oxidoreductase protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like nitrite and sulphite reductase 4Fe-4S region BFD-like [2Fe-2S]-binding region; KEGG: eca:ECA2991 nitrite reductase [NAD(P)H] large subunit. | 0.993 |
Tcr_1159 | Tcr_1158 | Tcr_1159 | Tcr_1158 | Assimilatory nitrate reductase (NADH) alpha subunit apoprotein; PFAM: molybdopterin oxidoreductase molydopterin dinucleotide-binding region molybdopterin oxidoreductase Fe4S4 region BFD-like [2Fe-2S]-binding region; KEGG: nasA, RSp1219; probable nitrate reductase large subunit oxidoreductase protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | KEGG: aci:ACIAD1909 putative nitrate reductase (electron transfer subunit) and putative nitrite reductase (small subunit). | 0.992 |
Tcr_1159 | Tcr_1488 | Tcr_1159 | Tcr_1488 | Assimilatory nitrate reductase (NADH) alpha subunit apoprotein; PFAM: molybdopterin oxidoreductase molydopterin dinucleotide-binding region molybdopterin oxidoreductase Fe4S4 region BFD-like [2Fe-2S]-binding region; KEGG: nasA, RSp1219; probable nitrate reductase large subunit oxidoreductase protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. | Ketohexokinase; PFAM: Rieske [2Fe-2S] region PfkB; KEGG: hsa:3795 ketohexokinase (fructokinase). | 0.655 |