STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
cysGuroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (473 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.995
Tcr_0113
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.969
Tcr_1158
KEGG: aci:ACIAD1909 putative nitrate reductase (electron transfer subunit) and putative nitrite reductase (small subunit).
  
  
 0.965
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.957
Tcr_0154
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: vfi:VF0053 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
  
 0.932
Tcr_1159
Assimilatory nitrate reductase (NADH) alpha subunit apoprotein; PFAM: molybdopterin oxidoreductase molydopterin dinucleotide-binding region molybdopterin oxidoreductase Fe4S4 region BFD-like [2Fe-2S]-binding region; KEGG: nasA, RSp1219; probable nitrate reductase large subunit oxidoreductase protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
 
  
 0.907
Tcr_1488
Ketohexokinase; PFAM: Rieske [2Fe-2S] region PfkB; KEGG: hsa:3795 ketohexokinase (fructokinase).
  
  
 0.864
Tcr_1893
PFAM: oxidoreductase FAD/NAD(P)-binding FAD-binding; KEGG: bha:BH0609 sulfite reductase (NADPH).
  
  
 0.863
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.861
Tcr_1157
TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like nitrite and sulphite reductase 4Fe-4S region BFD-like [2Fe-2S]-binding region; KEGG: eca:ECA2991 nitrite reductase [NAD(P)H] large subunit.
  
 0.849
Your Current Organism:
Hydrogenovibrio crunogenus
NCBI taxonomy Id: 317025
Other names: H. crunogenus XCL-2, Hydrogenovibrio crunogenus XCL-2, Thiomicrospira crunogena XCL-2
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