STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
glnDUTP-GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (888 aa)    
Predicted Functional Partners:
Tcr_1499
PFAM: nitrogen regulatory protein P-II; KEGG: bbr:BB2035 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.958
Tcr_1339
PFAM: nitrogen regulatory protein P-II; KEGG: cvi:CV2045 nitrogen regulatory protein P-II-1; Belongs to the P(II) protein family.
 
 
 0.956
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.775
map
Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
    0.771
Tcr_0912
PFAM: nitrogen regulatory protein P-II; KEGG: aci:ACIAD0244 regulatory protein, P-II 2, for nitrogen assimilation by glutamine synthetase, regulates GlnL (NRII) and GlnE (ATase).
 
 
 
 0.615
Tcr_1957
PFAM: glutamine amidotransferase, class-II glutamate synthase, alpha subunit-like ferredoxin-dependent glutamate synthase glutamate synthase; KEGG: pst:PSPTO5123 glutamate synthase, large subunit.
     
 0.604
bamA
Surface antigen family protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.573
rpsB
PFAM: ribosomal protein S2; KEGG: pae:PA3656 30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.
     
 0.558
Tcr_0905
Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region, ATPase-like histidine kinase A-like; KEGG: mca:MCA2542 nitrogen regulation protein NR(II).
  
 
 
 0.557
cysG
uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
  
   
 0.498
Your Current Organism:
Hydrogenovibrio crunogenus
NCBI taxonomy Id: 317025
Other names: H. crunogenus XCL-2, Hydrogenovibrio crunogenus XCL-2, Thiomicrospira crunogena XCL-2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.