node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tcr_1112 | Tcr_1643 | Tcr_1112 | Tcr_1643 | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | 0.662 |
Tcr_1112 | dnaJ | Tcr_1112 | Tcr_0871 | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.730 |
Tcr_1112 | dnaK | Tcr_1112 | Tcr_0870 | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.964 |
Tcr_1112 | groL | Tcr_1112 | Tcr_0346 | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Chaperonin 60 kDa subunit (groEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.664 |
Tcr_1112 | grpE | Tcr_1112 | Tcr_0869 | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | GrpE chaparone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | 0.868 |
Tcr_1112 | hslU | Tcr_1112 | Tcr_0404 | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | ATP-dependent hsl protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.623 |
Tcr_1112 | hslV | Tcr_1112 | Tcr_0410 | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | CodW component of CodWX peptidase. Threonine peptidase. MEROPS family T01B; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.537 |
Tcr_1112 | htpG | Tcr_1112 | Tcr_1609 | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.680 |
Tcr_1112 | lon2 | Tcr_1112 | Tcr_1548 | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | PIM1 peptidase. Serine peptidase. MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.640 |
Tcr_1643 | Tcr_1112 | Tcr_1643 | Tcr_1112 | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | 0.662 |
Tcr_1643 | clpB | Tcr_1643 | Tcr_0414 | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | ATPase family associated with various cellular activities; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.662 |
Tcr_1643 | dnaJ | Tcr_1643 | Tcr_0871 | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.848 |
Tcr_1643 | dnaK | Tcr_1643 | Tcr_0870 | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.980 |
Tcr_1643 | groL | Tcr_1643 | Tcr_0346 | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | Chaperonin 60 kDa subunit (groEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.875 |
Tcr_1643 | grpE | Tcr_1643 | Tcr_0869 | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | GrpE chaparone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | 0.730 |
Tcr_1643 | hslU | Tcr_1643 | Tcr_0404 | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | ATP-dependent hsl protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.714 |
Tcr_1643 | hslV | Tcr_1643 | Tcr_0410 | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | CodW component of CodWX peptidase. Threonine peptidase. MEROPS family T01B; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.726 |
Tcr_1643 | lon2 | Tcr_1643 | Tcr_1548 | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | PIM1 peptidase. Serine peptidase. MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.622 |
clpB | Tcr_1643 | Tcr_0414 | Tcr_1643 | ATPase family associated with various cellular activities; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Conserved hypothetical protein; KEGG: xac:XAC1101 heat shock protein G homolog. | 0.662 |
clpB | dnaJ | Tcr_0414 | Tcr_0871 | ATPase family associated with various cellular activities; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.731 |