STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (337 aa)    
Predicted Functional Partners:
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.999
gcvH
Glycine cleavage system H protein homolog; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.950
Tcr_1003
TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment FAD-dependent pyridine nucleotide-disulphide oxidoreductase pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: bbr:BB2538 dihydrolipoamide dehydrogenase.
 
  
 0.747
Tcr_1002
Pyruvate dehydrogenase complex, E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
  
 0.607
Tcr_1637
PFAM: protein of unknown function DUF493; KEGG: neu:NE1487 hypothetical protein; Belongs to the UPF0250 family.
  
  
 0.596
Tcr_1636
D-amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: mca:MCA0106 D-amino acid aminotransferase, putative.
       0.562
Tcr_1640
Hypothetical protein.
       0.539
Tcr_1635
Penicillin-binding protein 6. Serine peptidase. MEROPS family S11; PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1; KEGG: mca:MCA0105 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family.
       0.534
Tcr_0244
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
   
    0.510
obg
GTP-binding protein, GTP1/Obg family; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
 
      0.500
Your Current Organism:
Hydrogenovibrio crunogenus
NCBI taxonomy Id: 317025
Other names: H. crunogenus XCL-2, Hydrogenovibrio crunogenus XCL-2, Thiomicrospira crunogena XCL-2
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