node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sala_0036 | Sala_0037 | Sala_0036 | Sala_0037 | Methionine synthase (B12-dependent). | Methionine synthase (B12-dependent). | 0.999 |
Sala_0036 | Sala_1871 | Sala_0036 | Sala_1871 | Methionine synthase (B12-dependent). | Glycine cleavage system T protein. | 0.932 |
Sala_0036 | Sala_2360 | Sala_0036 | Sala_2360 | Methionine synthase (B12-dependent). | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.916 |
Sala_0036 | fmt | Sala_0036 | Sala_0249 | Methionine synthase (B12-dependent). | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.907 |
Sala_0036 | glyA | Sala_0036 | Sala_0791 | Methionine synthase (B12-dependent). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
Sala_0036 | metG | Sala_0036 | Sala_1259 | Methionine synthase (B12-dependent). | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | 0.910 |
Sala_0036 | purN | Sala_0036 | Sala_1758 | Methionine synthase (B12-dependent). | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.913 |
Sala_0037 | Sala_0036 | Sala_0037 | Sala_0036 | Methionine synthase (B12-dependent). | Methionine synthase (B12-dependent). | 0.999 |
Sala_0037 | Sala_1871 | Sala_0037 | Sala_1871 | Methionine synthase (B12-dependent). | Glycine cleavage system T protein. | 0.919 |
Sala_0037 | Sala_2360 | Sala_0037 | Sala_2360 | Methionine synthase (B12-dependent). | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.900 |
Sala_0037 | fmt | Sala_0037 | Sala_0249 | Methionine synthase (B12-dependent). | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.903 |
Sala_0037 | glyA | Sala_0037 | Sala_0791 | Methionine synthase (B12-dependent). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
Sala_0037 | metG | Sala_0037 | Sala_1259 | Methionine synthase (B12-dependent). | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. | 0.903 |
Sala_0037 | purN | Sala_0037 | Sala_1758 | Methionine synthase (B12-dependent). | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
Sala_1871 | Sala_0036 | Sala_1871 | Sala_0036 | Glycine cleavage system T protein. | Methionine synthase (B12-dependent). | 0.932 |
Sala_1871 | Sala_0037 | Sala_1871 | Sala_0037 | Glycine cleavage system T protein. | Methionine synthase (B12-dependent). | 0.919 |
Sala_1871 | Sala_2360 | Sala_1871 | Sala_2360 | Glycine cleavage system T protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.924 |
Sala_1871 | fmt | Sala_1871 | Sala_0249 | Glycine cleavage system T protein. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.931 |
Sala_1871 | folD | Sala_1871 | Sala_3097 | Glycine cleavage system T protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.964 |
Sala_1871 | glyA | Sala_1871 | Sala_0791 | Glycine cleavage system T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |