node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sfri_0872 | Sfri_1369 | Sfri_0872 | Sfri_1369 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: son:SO1812 methionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase. | 0.974 |
Sfri_0872 | Sfri_2024 | Sfri_0872 | Sfri_2024 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: aminotransferase, class I and II; KEGG: son:SO2350 aspartate aminotransferase. | 0.912 |
Sfri_0872 | Sfri_2915 | Sfri_0872 | Sfri_2915 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; KEGG: son:SO1362 prephenate dehydrogenase / chorismate mutase. | 0.531 |
Sfri_0872 | Sfri_3578 | Sfri_0872 | Sfri_3578 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin-independent synthase MetE, N-terminal domain protein; KEGG: cps:CPS_1151 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | 0.979 |
Sfri_0872 | hisC | Sfri_0872 | Sfri_1718 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: son:SO2072 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.416 |
Sfri_0872 | metK | Sfri_0872 | Sfri_0646 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.952 |
Sfri_1328 | Sfri_2024 | Sfri_1328 | Sfri_2024 | KEGG: son:SO1666 phenylalanine-4-hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: aromatic amino acid hydroxylase. | PFAM: aminotransferase, class I and II; KEGG: son:SO2350 aspartate aminotransferase. | 0.965 |
Sfri_1328 | Sfri_2327 | Sfri_1328 | Sfri_2327 | KEGG: son:SO1666 phenylalanine-4-hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: aromatic amino acid hydroxylase. | KEGG: son:SO1962 4-hydroxyphenylpyruvate dioxygenase; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. | 0.911 |
Sfri_1328 | Sfri_2913 | Sfri_1328 | Sfri_2913 | KEGG: son:SO1666 phenylalanine-4-hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: aromatic amino acid hydroxylase. | TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; KEGG: son:SO1367 prephenate dehydratase / chorismate mutase / phospho-2-dehydro-3-deoxyheptonate aldolase. | 0.936 |
Sfri_1328 | hisC | Sfri_1328 | Sfri_1718 | KEGG: son:SO1666 phenylalanine-4-hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: aromatic amino acid hydroxylase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: son:SO2072 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.910 |
Sfri_1328 | katG1 | Sfri_1328 | Sfri_1917 | KEGG: son:SO1666 phenylalanine-4-hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: aromatic amino acid hydroxylase. | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. | 0.900 |
Sfri_1369 | Sfri_0872 | Sfri_1369 | Sfri_0872 | KEGG: son:SO1812 methionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.974 |
Sfri_1369 | Sfri_2024 | Sfri_1369 | Sfri_2024 | KEGG: son:SO1812 methionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase. | PFAM: aminotransferase, class I and II; KEGG: son:SO2350 aspartate aminotransferase. | 0.907 |
Sfri_1369 | Sfri_2913 | Sfri_1369 | Sfri_2913 | KEGG: son:SO1812 methionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase. | TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; KEGG: son:SO1367 prephenate dehydratase / chorismate mutase / phospho-2-dehydro-3-deoxyheptonate aldolase. | 0.502 |
Sfri_1369 | Sfri_3578 | Sfri_1369 | Sfri_3578 | KEGG: son:SO1812 methionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase. | PFAM: Methionine synthase, vitamin-B12 independent; Cobalamin-independent synthase MetE, N-terminal domain protein; KEGG: cps:CPS_1151 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | 0.955 |
Sfri_1369 | metK | Sfri_1369 | Sfri_0646 | KEGG: son:SO1812 methionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.921 |
Sfri_2024 | Sfri_0872 | Sfri_2024 | Sfri_0872 | PFAM: aminotransferase, class I and II; KEGG: son:SO2350 aspartate aminotransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.912 |
Sfri_2024 | Sfri_1328 | Sfri_2024 | Sfri_1328 | PFAM: aminotransferase, class I and II; KEGG: son:SO2350 aspartate aminotransferase. | KEGG: son:SO1666 phenylalanine-4-hydroxylase; TIGRFAM: phenylalanine-4-hydroxylase; PFAM: aromatic amino acid hydroxylase. | 0.965 |
Sfri_2024 | Sfri_1369 | Sfri_2024 | Sfri_1369 | PFAM: aminotransferase, class I and II; KEGG: son:SO2350 aspartate aminotransferase. | KEGG: son:SO1812 methionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase. | 0.907 |
Sfri_2024 | Sfri_2327 | Sfri_2024 | Sfri_2327 | PFAM: aminotransferase, class I and II; KEGG: son:SO2350 aspartate aminotransferase. | KEGG: son:SO1962 4-hydroxyphenylpyruvate dioxygenase; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. | 0.960 |