node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sfri_3084 | Sfri_3571 | Sfri_3084 | Sfri_3571 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: ppr:PBPRB1018 putative deoxycytidylate deaminase. | 0.443 |
Sfri_3084 | dut | Sfri_3084 | Sfri_3830 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.419 |
Sfri_3084 | folD | Sfri_3084 | Sfri_2598 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.407 |
Sfri_3084 | gcvT | Sfri_3084 | Sfri_3151 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.925 |
Sfri_3084 | glyA | Sfri_3084 | Sfri_1033 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.940 |
Sfri_3084 | tdk | Sfri_3084 | Sfri_2745 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: thymidine kinase; KEGG: son:SO3140 thymidine kinase. | 0.501 |
Sfri_3084 | thyA | Sfri_3084 | Sfri_2942 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
Sfri_3084 | tmk | Sfri_3084 | Sfri_2240 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.418 |
Sfri_3391 | Sfri_3571 | Sfri_3391 | Sfri_3571 | KEGG: sai:Saci_1672 conserved crenarchaeal protein. | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: ppr:PBPRB1018 putative deoxycytidylate deaminase. | 0.907 |
Sfri_3391 | dut | Sfri_3391 | Sfri_3830 | KEGG: sai:Saci_1672 conserved crenarchaeal protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.912 |
Sfri_3391 | tdk | Sfri_3391 | Sfri_2745 | KEGG: sai:Saci_1672 conserved crenarchaeal protein. | PFAM: thymidine kinase; KEGG: son:SO3140 thymidine kinase. | 0.906 |
Sfri_3391 | thyA | Sfri_3391 | Sfri_2942 | KEGG: sai:Saci_1672 conserved crenarchaeal protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.915 |
Sfri_3391 | tmk | Sfri_3391 | Sfri_2240 | KEGG: sai:Saci_1672 conserved crenarchaeal protein. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.912 |
Sfri_3547 | folD | Sfri_3547 | Sfri_2598 | KEGG: son:SO4054 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.939 |
Sfri_3547 | gcvT | Sfri_3547 | Sfri_3151 | KEGG: son:SO4054 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.941 |
Sfri_3547 | glyA | Sfri_3547 | Sfri_1033 | KEGG: son:SO4054 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
Sfri_3547 | thyA | Sfri_3547 | Sfri_2942 | KEGG: son:SO4054 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.935 |
Sfri_3571 | Sfri_3084 | Sfri_3571 | Sfri_3084 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: ppr:PBPRB1018 putative deoxycytidylate deaminase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.443 |
Sfri_3571 | Sfri_3391 | Sfri_3571 | Sfri_3391 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: ppr:PBPRB1018 putative deoxycytidylate deaminase. | KEGG: sai:Saci_1672 conserved crenarchaeal protein. | 0.907 |
Sfri_3571 | dut | Sfri_3571 | Sfri_3830 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: ppr:PBPRB1018 putative deoxycytidylate deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.946 |