node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sfri_0439 | Sfri_0466 | Sfri_0439 | Sfri_0466 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.859 |
Sfri_0439 | Sfri_1506 | Sfri_0439 | Sfri_1506 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: vvy:VVA0956 uroporphyrinogen-III methylase. | 0.920 |
Sfri_0439 | Sfri_2695 | Sfri_0439 | Sfri_2695 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: siroheme synthase; KEGG: son:SO3108 precorrin-2 oxidase / ferrochelatase. | 0.519 |
Sfri_0439 | Sfri_3188 | Sfri_0439 | Sfri_3188 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: son:SO3728 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.920 |
Sfri_0439 | hemA | Sfri_0439 | Sfri_0722 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.619 |
Sfri_0439 | hemC | Sfri_0439 | Sfri_0440 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
Sfri_0439 | hemE | Sfri_0439 | Sfri_0482 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.941 |
Sfri_0439 | hemH | Sfri_0439 | Sfri_2852 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.467 |
Sfri_0439 | hemL | Sfri_0439 | Sfri_2980 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: son:SO1300 glutamate-1-semialdehyde-2,1-aminomutase. | 0.525 |
Sfri_0466 | Sfri_0439 | Sfri_0466 | Sfri_0439 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.859 |
Sfri_0466 | Sfri_1506 | Sfri_0466 | Sfri_1506 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: vvy:VVA0956 uroporphyrinogen-III methylase. | 0.872 |
Sfri_0466 | Sfri_2695 | Sfri_0466 | Sfri_2695 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: siroheme synthase; KEGG: son:SO3108 precorrin-2 oxidase / ferrochelatase. | 0.560 |
Sfri_0466 | Sfri_3188 | Sfri_0466 | Sfri_3188 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: son:SO3728 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.874 |
Sfri_0466 | hemA | Sfri_0466 | Sfri_0722 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.882 |
Sfri_0466 | hemC | Sfri_0466 | Sfri_0440 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
Sfri_0466 | hemE | Sfri_0466 | Sfri_0482 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.782 |
Sfri_0466 | hemH | Sfri_0466 | Sfri_2852 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.536 |
Sfri_0466 | hemL | Sfri_0466 | Sfri_2980 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: son:SO1300 glutamate-1-semialdehyde-2,1-aminomutase. | 0.993 |
Sfri_1506 | Sfri_0439 | Sfri_1506 | Sfri_0439 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: vvy:VVA0956 uroporphyrinogen-III methylase. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.920 |
Sfri_1506 | Sfri_0466 | Sfri_1506 | Sfri_0466 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: vvy:VVA0956 uroporphyrinogen-III methylase. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: son:SO4208 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.872 |