STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hpbDMandelate racemase/muconate lactonizing enzyme, N-terminal domain protein; Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha- ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. Can also catalyze the racemization of L- proline betaine. (369 aa)    
Predicted Functional Partners:
Pden_1189
PFAM: Rieske [2Fe-2S] domain protein; KEGG: sme:SMa0751 putative aromatic-ring hydroxylating dioxygenase, alpha-subunit.
 
 
 0.838
Pden_1176
TIGRFAM: catechol 1,2-dioxygenase; PFAM: intradiol ring-cleavage dioxygenase; Catechol dioxygenase, N-terminal domain protein; KEGG: aci:ACIAD1442 catechol 1,2-dioxygenase.
 
  
 0.725
Pden_1188
PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: sme:SMa0752 possible dioxygenase reductase subunit.
 
  
 0.721
Pden_1186
Glutathione-independent formaldehyde dehydrogenase; PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: atc:AGR_C_2885 hypothetical protein.
  
  
 0.706
Pden_1184
Proline racemase; Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). Is likely involved in a degradation pathway that converts t3LHyp to L-proline, which would allow P.denitrificans to grow on t3LHyp as a sole carbon source. Displays neither proline racemase activity nor 4-hydroxyproline 2-epimerase activity.
 
   
 0.705
Pden_1175
PFAM: Muconolactone delta-isomerase; KEGG: bam:Bamb_6586 muconolactone delta-isomerase.
 
  
 0.697
Pden_1045
PFAM: proline racemase; KEGG: rha:RHA1_ro05288 probable proline racemase; Belongs to the proline racemase family.
 
   
 0.694
Pden_1197
PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ppu:PP_4753 N-methylproline demethylase, putative.
 
   
 0.691
Pden_3467
PFAM: proline racemase; KEGG: atc:AGR_L_1800 hypothetical protein.
     
 0.650
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
      
 0.632
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
Server load: low (30%) [HD]