STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nirEuroporphyrinogen-III C-methyltransferase; Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin (By similarity). Inactivation of uroporphyrinogen- III methyltransferase results in the loss of nitrite and nitric oxide reductase activities, but not of nitrous oxide reductase activity. Likely involved in heme D1 biosynthesis. (287 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.982
Pden_1997
Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.925
Pden_2556
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: bja:blr3273 probable Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
  
  
0.921
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.920
Pden_2535
TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rsp:RSP_2826 putative precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family.
  
 
 0.913
Pden_2492
Transcriptional regulator, AsnC family; KEGG: rde:RD1_1570 nitrite reductase heme biosynthesis G.
 
  
 0.880
Pden_2493
Transcriptional regulator, AsnC family; KEGG: sil:SPOA0226 nitrite reductase heme biosynthesis H protein.
 
  
 0.880
nirD
Transcriptional regulator, AsnC family; Required for the biosynthesis of heme D1 of nitrite reductase.
 
  
 0.867
Pden_3809
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: rsp:RSP_2848 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
  
 0.860
Pden_2494
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: sil:SPOA0227 nitrite reductase heme biosynthesis J protein.
 
  
 0.854
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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