node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pden_1385 | folD1 | Pden_1385 | Pden_2614 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: rsp:RSP_1898 putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.941 |
Pden_1385 | glyA | Pden_1385 | Pden_0920 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: rsp:RSP_1898 putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.460 |
Pden_1385 | purN | Pden_1385 | Pden_3927 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: rsp:RSP_1898 putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.933 |
Pden_1580 | folD1 | Pden_1580 | Pden_2614 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: rsp:RSP_0663 formate-tetrahydrofolate ligase. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.956 |
Pden_1580 | glyA | Pden_1580 | Pden_0920 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: rsp:RSP_0663 formate-tetrahydrofolate ligase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.533 |
Pden_1580 | purH | Pden_1580 | Pden_2718 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: rsp:RSP_0663 formate-tetrahydrofolate ligase. | IMP cyclohydrolase; KEGG: rsp:RSP_1100 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.773 |
Pden_1580 | purN | Pden_1580 | Pden_3927 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: rsp:RSP_0663 formate-tetrahydrofolate ligase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.539 |
Pden_2319 | Pden_2348 | Pden_2319 | Pden_2348 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: rsp:RSP_2172 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent. | 0.920 |
Pden_2319 | folD1 | Pden_2319 | Pden_2614 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: rsp:RSP_2172 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.954 |
Pden_2319 | glyA | Pden_2319 | Pden_0920 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: rsp:RSP_2172 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.955 |
Pden_2319 | purN | Pden_2319 | Pden_3927 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: rsp:RSP_2172 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.440 |
Pden_2348 | Pden_2319 | Pden_2348 | Pden_2319 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: rsp:RSP_2172 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.920 |
Pden_2348 | fhs1 | Pden_2348 | Pden_1317 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: rsp:RSP_0663 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.928 |
Pden_2348 | fmt | Pden_2348 | Pden_0642 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.916 |
Pden_2348 | folD1 | Pden_2348 | Pden_2614 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.961 |
Pden_2348 | glyA | Pden_2348 | Pden_0920 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
Pden_2348 | purH | Pden_2348 | Pden_2718 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent. | IMP cyclohydrolase; KEGG: rsp:RSP_1100 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.931 |
Pden_2348 | purN | Pden_2348 | Pden_3927 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.923 |
Pden_2348 | purU | Pden_2348 | Pden_2613 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.915 |
fhs1 | Pden_2348 | Pden_1317 | Pden_2348 | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: rsp:RSP_0663 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG: rsp:RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent. | 0.928 |