STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioB2Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (320 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.999
Pden_2917
8-amino-7-oxononanoate synthase; PFAM: aminotransferase, class I and II; KEGG: rpb:RPB_4344 8-amino-7-oxononanoate synthase.
  
 0.972
Pden_2919
TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: ngo:NGO0308 putative adenosylmethionine-8-amino-7-oxononanoate aminotranferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.969
Pden_2230
KEGG: sil:SPO2762 biotin--acetyl-CoA-carboxylase ligase; TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase.
  
 
 0.922
bioB1
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
  
 
0.902
Pden_2921
PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: cte:CT0049 biotin synthesis protein, putative.
 
   
 0.855
Pden_2920
PFAM: protein of unknown function DUF452; KEGG: nme:NMB0473 hypothetical protein.
 
     0.824
hemA
KEGG: rde:RD1_2827 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aminotransferase, class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  
 0.699
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.655
nadA
Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
  
  
 0.638
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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