node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pden_0488 | Pden_2556 | Pden_0488 | Pden_2556 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: rsp:RSP_1146 glutamine-pyruvate aminotransferase. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: bja:blr3273 probable Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.520 |
Pden_0488 | hemE | Pden_0488 | Pden_3629 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: rsp:RSP_1146 glutamine-pyruvate aminotransferase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.800 |
Pden_0488 | hemN | Pden_0488 | Pden_1851 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: rsp:RSP_1146 glutamine-pyruvate aminotransferase. | Oxygen-independent coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.679 |
Pden_0488 | nirE | Pden_0488 | Pden_2488 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: rsp:RSP_1146 glutamine-pyruvate aminotransferase. | uroporphyrinogen-III C-methyltransferase; Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin (By similarity). Inactivation of uroporphyrinogen- III methyltransferase results in the loss of nitrite and nitric oxide reductase activities, but not of nitrous oxide reductase activity. Likely involved in heme D1 biosynthesis. | 0.520 |
Pden_0488 | polA | Pden_0488 | Pden_1853 | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: rsp:RSP_1146 glutamine-pyruvate aminotransferase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.635 |
Pden_1752 | Pden_1997 | Pden_1752 | Pden_1997 | PFAM: coproporphyrinogen III oxidase; KEGG: rsp:RSP_0682 coproporphyrinogen III oxidase. | Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.440 |
Pden_1752 | hemC | Pden_1752 | Pden_3630 | PFAM: coproporphyrinogen III oxidase; KEGG: rsp:RSP_0682 coproporphyrinogen III oxidase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.621 |
Pden_1752 | hemE | Pden_1752 | Pden_3629 | PFAM: coproporphyrinogen III oxidase; KEGG: rsp:RSP_0682 coproporphyrinogen III oxidase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.981 |
Pden_1752 | hemH | Pden_1752 | Pden_2583 | PFAM: coproporphyrinogen III oxidase; KEGG: rsp:RSP_0682 coproporphyrinogen III oxidase. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.720 |
Pden_1752 | hemN | Pden_1752 | Pden_1851 | PFAM: coproporphyrinogen III oxidase; KEGG: rsp:RSP_0682 coproporphyrinogen III oxidase. | Oxygen-independent coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.953 |
Pden_1997 | Pden_1752 | Pden_1997 | Pden_1752 | Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | PFAM: coproporphyrinogen III oxidase; KEGG: rsp:RSP_0682 coproporphyrinogen III oxidase. | 0.440 |
Pden_1997 | Pden_2556 | Pden_1997 | Pden_2556 | Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: bja:blr3273 probable Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.925 |
Pden_1997 | hemC | Pden_1997 | Pden_3630 | Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.992 |
Pden_1997 | hemE | Pden_1997 | Pden_3629 | Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.945 |
Pden_1997 | hemH | Pden_1997 | Pden_2583 | Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.493 |
Pden_1997 | nirE | Pden_1997 | Pden_2488 | Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin (By similarity). Inactivation of uroporphyrinogen- III methyltransferase results in the loss of nitrite and nitric oxide reductase activities, but not of nitrous oxide reductase activity. Likely involved in heme D1 biosynthesis. | 0.925 |
Pden_2556 | Pden_0488 | Pden_2556 | Pden_0488 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: bja:blr3273 probable Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: rsp:RSP_1146 glutamine-pyruvate aminotransferase. | 0.520 |
Pden_2556 | Pden_1997 | Pden_2556 | Pden_1997 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: bja:blr3273 probable Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Putative uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.925 |
Pden_2556 | hemC | Pden_2556 | Pden_3630 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: bja:blr3273 probable Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.984 |
Pden_2556 | hemE | Pden_2556 | Pden_3629 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: bja:blr3273 probable Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.920 |