STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
bhcCD-3-hydroxyaspartate aldolase; Catalyzes the condensation of glyoxylate and glycine into (2R,3S)-beta-hydroxyaspartate ((3S)-3-hydroxy-D-aspartate). Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Is also able to catalyze the reverse reaction in vitro, i.e. the cleavage of (3S)-3-hydroxy-D- aspartate, and that of D-threonine to a lesser extent. Belongs to the DSD1 family. (387 aa)    
Predicted Functional Partners:
bhcD
Ornithine cyclodeaminase; Imine reductase that catalyzes the NADH-dependent reduction of iminosuccinate to L-aspartate. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Thereby BhcD regenerates the amino group donor for the first step of the BHAC.
 
   
 0.981
bhcB
Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; Catalyzes the dehydration of (2R,3S)-beta-hydroxyaspartate ((3S)-3-hydroxy-D-aspartate) into iminosuccinate. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta- hydroxyaspartate cycle (BHAC).
 
   
 0.971
bhcA
Serine-glyoxylate aminotransferase apoenzyme; Catalyzes the transamination of glyoxylate into glycine using L-aspartate as the preferred amino group donor. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta- hydroxyaspartate cycle (BHAC). Can catalyze the reverse reaction in vitro, and also use L-serine and L-glutamate as amino group donor, but with much less efficiency than L-aspartate.
 
     0.894
bhcR
Transcriptional regulator, IclR family; Transcriptional regulator of the bhc gene cluster involved in glycolate and glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Glyoxylate negatively affects the interaction of BhcR with the promoter region of the bhc gene cluster.
 
    0.735
Pden_3916
PFAM: amidohydrolase; Amidohydrolase 3; KEGG: sil:SPO2957 hydroxydechloroatrazine ethylaminohydrolase.
       0.651
Pden_3917
TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: sme:SMc02512 putative permease transmembrane protein.
       0.642
Pden_3915
PFAM: Transthyretin; KEGG: rde:RD1_4150 hypothetical protein; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
       0.622
Pden_0563
Citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; KEGG: rsp:RSP_0970 putative citrate lyase beta chain; Belongs to the HpcH/HpaI aldolase family.
      
 0.497
Pden_0566
PFAM: MaoC domain protein dehydratase; KEGG: sil:SPO0355 hypothetical protein.
      
 0.497
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
      
 0.497
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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