STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
bhcRTranscriptional regulator, IclR family; Transcriptional regulator of the bhc gene cluster involved in glycolate and glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Glyoxylate negatively affects the interaction of BhcR with the promoter region of the bhc gene cluster. (279 aa)    
Predicted Functional Partners:
Pden_0322
PFAM: Allophanate hydrolase subunit 2; Allophanate hydrolase subunit 1; KEGG: atc:AGR_L_1866 hypothetical protein.
  
    0.816
bhcC
D-3-hydroxyaspartate aldolase; Catalyzes the condensation of glyoxylate and glycine into (2R,3S)-beta-hydroxyaspartate ((3S)-3-hydroxy-D-aspartate). Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Is also able to catalyze the reverse reaction in vitro, i.e. the cleavage of (3S)-3-hydroxy-D- aspartate, and that of D-threonine to a lesser extent. Belongs to the DSD1 family.
 
    0.735
bhcD
Ornithine cyclodeaminase; Imine reductase that catalyzes the NADH-dependent reduction of iminosuccinate to L-aspartate. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). Thereby BhcD regenerates the amino group donor for the first step of the BHAC.
 
     0.697
bhcB
Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; Catalyzes the dehydration of (2R,3S)-beta-hydroxyaspartate ((3S)-3-hydroxy-D-aspartate) into iminosuccinate. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta- hydroxyaspartate cycle (BHAC).
 
    0.645
bhcA
Serine-glyoxylate aminotransferase apoenzyme; Catalyzes the transamination of glyoxylate into glycine using L-aspartate as the preferred amino group donor. Is essential for the growth of P.denitrificans in the presence of glycolate and glyoxylate since it functions in glyoxylate assimilation via the beta- hydroxyaspartate cycle (BHAC). Can catalyze the reverse reaction in vitro, and also use L-serine and L-glutamate as amino group donor, but with much less efficiency than L-aspartate.
 
    0.632
Pden_0188
PFAM: regulatory proteins, IclR; KEGG: bps:BPSS2127 IclR transcriptional regulator protein.
  
     0.579
Pden_3248
PFAM: regulatory proteins, IclR; KEGG: rha:RHA1_ro06686 probable transciptional regulator, IclR family.
  
     0.571
Pden_3923
Hypothetical protein.
       0.495
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans PD1222
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