node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pden_2882 | Pden_4463 | Pden_2882 | Pden_4463 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sit:TM1040_1548 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.908 |
Pden_2882 | adk | Pden_2882 | Pden_0781 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sit:TM1040_1548 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.903 |
Pden_2882 | apt | Pden_2882 | Pden_3620 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sit:TM1040_1548 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.912 |
Pden_2882 | guaA | Pden_2882 | Pden_3696 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sit:TM1040_1548 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.914 |
Pden_2882 | guaB | Pden_2882 | Pden_0592 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sit:TM1040_1548 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.909 |
Pden_2882 | purA | Pden_2882 | Pden_0603 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sit:TM1040_1548 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.909 |
Pden_2882 | purH | Pden_2882 | Pden_2718 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sit:TM1040_1548 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | IMP cyclohydrolase; KEGG: rsp:RSP_1100 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.909 |
Pden_2882 | surE | Pden_2882 | Pden_2731 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sit:TM1040_1548 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.913 |
Pden_4463 | Pden_2882 | Pden_4463 | Pden_2882 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sit:TM1040_1548 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | 0.908 |
Pden_4463 | adk | Pden_4463 | Pden_0781 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.939 |
Pden_4463 | apt | Pden_4463 | Pden_3620 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.946 |
Pden_4463 | argH | Pden_4463 | Pden_2022 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: sil:SPO0332 argininosuccinate lyase. | 0.916 |
Pden_4463 | guaA | Pden_4463 | Pden_3696 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.949 |
Pden_4463 | guaB | Pden_4463 | Pden_0592 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.938 |
Pden_4463 | purA | Pden_4463 | Pden_0603 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.998 |
Pden_4463 | purC | Pden_4463 | Pden_2861 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | KEGG: rde:RD1_2262 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. | 0.995 |
Pden_4463 | purH | Pden_4463 | Pden_2718 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | IMP cyclohydrolase; KEGG: rsp:RSP_1100 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.988 |
Pden_4463 | surE | Pden_4463 | Pden_2731 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.920 |
adk | Pden_2882 | Pden_0781 | Pden_2882 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: sit:TM1040_1548 5'-nucleotidase-like; Belongs to the 5'-nucleotidase family. | 0.903 |
adk | Pden_4463 | Pden_0781 | Pden_4463 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: rsp:RSP_2221 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.939 |