node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pden_0285 | Pden_1933 | Pden_0285 | Pden_1933 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_PF00182 probable threonine dehydratase protein. | KEGG: sit:TM1040_0585 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | 0.812 |
Pden_0285 | Pden_1935 | Pden_0285 | Pden_1935 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_PF00182 probable threonine dehydratase protein. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.893 |
Pden_0285 | Pden_3678 | Pden_0285 | Pden_3678 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_PF00182 probable threonine dehydratase protein. | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: rsp:RSP_0403 homoserine dehydrogenase. | 0.400 |
Pden_0285 | Pden_4132 | Pden_0285 | Pden_4132 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_PF00182 probable threonine dehydratase protein. | KEGG: rsp:RSP_0361 probable L-serine dehydratase protein; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.922 |
Pden_0285 | ilvA | Pden_0285 | Pden_0497 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_PF00182 probable threonine dehydratase protein. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.925 |
Pden_0285 | metAA | Pden_0285 | Pden_4499 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_PF00182 probable threonine dehydratase protein. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.818 |
Pden_0285 | metZ | Pden_0285 | Pden_4298 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_PF00182 probable threonine dehydratase protein. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.862 |
Pden_0285 | trpB | Pden_0285 | Pden_3791 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_PF00182 probable threonine dehydratase protein. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.930 |
Pden_1933 | Pden_0285 | Pden_1933 | Pden_0285 | KEGG: sit:TM1040_0585 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_PF00182 probable threonine dehydratase protein. | 0.812 |
Pden_1933 | Pden_1935 | Pden_1933 | Pden_1935 | KEGG: sit:TM1040_0585 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.965 |
Pden_1933 | Pden_3678 | Pden_1933 | Pden_3678 | KEGG: sit:TM1040_0585 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: rsp:RSP_0403 homoserine dehydrogenase. | 0.890 |
Pden_1933 | ilvA | Pden_1933 | Pden_0497 | KEGG: sit:TM1040_0585 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.812 |
Pden_1933 | metAA | Pden_1933 | Pden_4499 | KEGG: sit:TM1040_0585 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.990 |
Pden_1933 | metZ | Pden_1933 | Pden_4298 | KEGG: sit:TM1040_0585 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.942 |
Pden_1935 | Pden_0285 | Pden_1935 | Pden_0285 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_PF00182 probable threonine dehydratase protein. | 0.893 |
Pden_1935 | Pden_1933 | Pden_1935 | Pden_1933 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: sit:TM1040_0585 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | 0.965 |
Pden_1935 | Pden_2319 | Pden_1935 | Pden_2319 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: rsp:RSP_2172 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.998 |
Pden_1935 | Pden_3678 | Pden_1935 | Pden_3678 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: rsp:RSP_0403 homoserine dehydrogenase. | 0.949 |
Pden_1935 | ilvA | Pden_1935 | Pden_0497 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.893 |
Pden_1935 | metAA | Pden_1935 | Pden_4499 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.877 |