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folD2 protein (Paracoccus denitrificans) - STRING interaction network
"folD2" - Bifunctional protein FolD 2 in Paracoccus denitrificans
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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folD2Bifunctional protein FolD 2; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (302 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (427 aa)
 
 
  0.983
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) (294 aa)
 
 
  0.974
purH
Bifunctional purine biosynthesis protein PurH; KEGG- rsp-RSP_1100 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM- phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM- MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region (529 aa)
   
  0.966
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (198 aa)
 
 
  0.957
Pden_2348
TIGRFAM- glycine cleavage system T protein; PFAM- glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; KEGG- rsp-RSP_2193 predicted aminomethyltransferase, tetrahydrofolate dependent (370 aa)
   
 
  0.949
fhs1
PFAM- formate-tetrahydrofolate ligase, FTHFS; KEGG- rsp-RSP_0663 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family (555 aa)
 
 
  0.948
Pden_1317
PFAM- formate-tetrahydrofolate ligase, FTHFS; KEGG- rsp-RSP_0663 formate-tetrahydrofolate ligase (555 aa)
 
 
  0.948
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus (297 aa)
 
  0.937
Pden_2319
TIGRFAM- 5,10-methylenetetrahydrofolate reductase; PFAM- methylenetetrahydrofolate reductase; KEGG- rsp-RSP_2172 5,10-methylenetetrahydrofolate reductase (287 aa)
   
 
  0.933
Pden_4907
TIGRFAM- sarcosine oxidase, alpha subunit family; PFAM- glycine cleavage T protein (aminomethyl transferase); FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Glycine cleavage T-protein, C-terminal barrel; KEGG- sit-TM1040_3377 sarcosine oxidase, alpha subunit family; Belongs to the GcvT family (976 aa)
   
   
  0.922
Your Current Organism:
Paracoccus denitrificans
NCBI taxonomy Id: 318586
Other names: P. denitrificans PD1222, Paracoccus denitrificans, Paracoccus denitrificans PD1222
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