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leuA protein (Shewanella putrefaciens) - STRING interaction network
"leuA" - 2-isopropylmalate synthase in Shewanella putrefaciens
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Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily (522 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (474 aa)
 
  0.999
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the LeuD family. LeuD type 1 subfamily (201 aa)
 
 
  0.998
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (364 aa)
 
 
  0.995
ilvD
KEGG- shm-Shewmr7_3662 dihydroxy-acid dehydratase; TIGRFAM- dihydroxy-acid dehydratase; PFAM- dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family (619 aa)
 
 
  0.976
ABP77322.1
TIGRFAM- acetolactate synthase, large subunit, biosynthetic type; PFAM- thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG- she-Shewmr4_0362 acetolactate synthase, large subunit, biosynthetic type (557 aa)
 
 
  0.957
ABP77357.1
KEGG- shm-Shewmr7_0310 branched-chain amino acid aminotransferase; TIGRFAM- branched-chain amino acid aminotransferase; PFAM- aminotransferase, class IV (363 aa)
   
  0.948
ABP75859.1
TIGRFAM- acetolactate synthase, large subunit, biosynthetic type; PFAM- thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG- she-Shewmr4_1750 acetolactate synthase, large subunit, biosynthetic type (572 aa)
 
 
  0.945
ABP75783.1
L-arabinonate dehydratase; PFAM- dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG- shm-Shewmr7_1991 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family (577 aa)
 
 
  0.940
ABP75535.1
PFAM- iron-containing alcohol dehydrogenase; aldehyde dehydrogenase; KEGG- she-Shewmr4_1683 iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family (870 aa)
   
 
  0.930
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family (650 aa)
   
 
  0.926
Your Current Organism:
Shewanella putrefaciens
NCBI taxonomy Id: 319224
Other names: S. putrefaciens CN-32, Shewanella putrefaciens, Shewanella putrefaciens CN-32, Shewanella putrefaciens str. CN-32, Shewanella putrefaciens strain CN-32
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