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ABP74349.1 protein (Shewanella putrefaciens) - STRING interaction network
"ABP74349.1" - TIGRFAM: 5,10-methylenetetrahydrofolate reductase in Shewanella putrefaciens
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ABP74349.1TIGRFAM- 5,10-methylenetetrahydrofolate reductase; PFAM- methylenetetrahydrofolate reductase; KEGG- son-SO4054 5,10-methylenetetrahydrofolate reductase (295 aa)    
Predicted Functional Partners:
ABP76680.1
TIGRFAM- methionine synthase; PFAM- dihydropteroate synthase, DHPS; homocysteine S-methyltransferase; Methionine synthase, B12-binding module, cap domain protein; Vitamin B12 dependent methionine synthase, activation region; cobalamin B12-binding domain protein; KEGG- son-SO1030 5-methyltetrahydrofolate--homocysteine methyltransferase (1244 aa)
 
  0.983
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family (962 aa)
   
 
  0.969
metE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (756 aa)
 
  0.957
folD
Bifunctional protein FolD; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (284 aa)
   
 
  0.956
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (417 aa)
   
 
  0.952
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (364 aa)
   
 
  0.941
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis (264 aa)
   
 
  0.935
ABP74348.1
KEGG- son-SO4055 aspartokinase II/homoserine dehydrogenase, methionine-sensitive; TIGRFAM- aspartate kinase; PFAM- aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding (797 aa)
   
 
  0.904
ABP74347.1
KEGG- son-SO4056 cystathionine gamma-synthase; TIGRFAM- O-succinylhomoserine (thiol)-lyase; PFAM- Cys/Met metabolism pyridoxal-phosphate-dependent enzymes (387 aa)
   
 
  0.880
ABP76885.1
Transcriptional regulator, LysR family; PFAM- regulatory protein, LysR; LysR, substrate-binding; KEGG- shm-Shewmr7_0653 transcriptional regulator, LysR family (301 aa)
   
   
  0.859
Your Current Organism:
Shewanella putrefaciens
NCBI taxonomy Id: 319224
Other names: S. putrefaciens CN-32, Shewanella putrefaciens, Shewanella putrefaciens CN-32, Shewanella putrefaciens str. CN-32, Shewanella putrefaciens strain CN-32
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