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ABP74713.1 protein (Shewanella putrefaciens) - STRING interaction network
"ABP74713.1" - Dihydrofolate reductase in Shewanella putrefaciens
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Predicted Interactions
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textmining
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ABP74713.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (160 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2’-deoxyuridine- 5’-monophosphate (dUMP) to 2’-deoxythymidine-5’-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis (264 aa)
  0.999
ABP76161.1
KEGG- she-Shewmr4_1427 FolC bifunctional protein; TIGRFAM- FolC bifunctional protein; PFAM- cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; Belongs to the folylpolyglutamate synthase family (423 aa)
 
  0.964
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (417 aa)
   
  0.960
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus (318 aa)
   
  0.930
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family (962 aa)
   
 
  0.929
fhs
PFAM- formate-tetrahydrofolate ligase, FTHFS; KEGG- son-SO0560 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family (570 aa)
   
 
  0.927
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (214 aa)
   
 
  0.916
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (364 aa)
   
 
  0.915
purH
Bifunctional purine biosynthesis protein PurH; KEGG- son-SO0442 phosphoribosylaminoimidazolecarboxamide formyltransferase (543 aa)
     
  0.910
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) (316 aa)
       
  0.903
Your Current Organism:
Shewanella putrefaciens
NCBI taxonomy Id: 319224
Other names: S. putrefaciens CN-32, Shewanella putrefaciens, Shewanella putrefaciens CN-32, Shewanella putrefaciens str. CN-32, Shewanella putrefaciens strain CN-32
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