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glyA protein (Deinococcus geothermalis) - STRING interaction network
"glyA" - Serine hydroxymethyltransferase in Deinococcus geothermalis
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (412 aa)    
Predicted Functional Partners:
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (374 aa)
 
  0.997
purH
Bifunctional purine biosynthesis protein PurH; KEGG- dra-DR0868 phosphoribosylaminoimidazolecarboxamide formyltransferase (514 aa)
   
  0.992
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family (954 aa)
 
 
  0.992
folD2
Bifunctional protein FolD 2; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (289 aa)
 
 
  0.984
folD1
Bifunctional protein FolD 1; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (288 aa)
 
 
  0.982
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (120 aa)
   
 
  0.967
Dgeo_1546
PFAM- formyl transferase-like- (3.1e-40); KEGG- dra-DR2026 phosphoribosylglycinamide formyltransferase , ev=1e-78, 80% identity (190 aa)
   
 
  0.962
Dgeo_1336
TIGRFAM- 5-methyltetrahydrofolate--homocysteine methyltransferase- (0); PFAM- dihydropteroate synthase, DHPS- (1.1e-74) homocysteine S-methyltransferase- (1.5e-140) Methionine synthase, B12-binding module, cap- (2e-42) Vitamin B12 dependent methionine synthase, activation region- (2.2e-74) cobalamin B12-binding- (2.2e-25); KEGG- dra-DR0966 5-methyltetrahydrofolate--homocysteine methyltransferase , ev=0.0, 83% identity (1226 aa)
   
 
  0.954
Dgeo_1451
Threonine aldolase; PFAM- aromatic amino acid beta-eliminating lyase/threonine aldolase- (3.9e-148) aminotransferase, class I and II- (9.3e-06); KEGG- dra-DR1313 L-allo-threonine aldolase , ev=1e-150, 80% identity (345 aa)
     
  0.950
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus (319 aa)
   
 
  0.948
Your Current Organism:
Deinococcus geothermalis
NCBI taxonomy Id: 319795
Other names: D. geothermalis DSM 11300, Deinococcus geothermalis, Deinococcus geothermalis AG-3a, Deinococcus geothermalis CIP 105573, Deinococcus geothermalis DSM 11300, Deinococcus geothermalis DSM11300, Deinococcus geothermalis str. DSM 11300, Deinococcus geothermalis strain DSM 11300
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