STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa)    
Predicted Functional Partners:
Dgeo_0300
5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
 
 
 0.999
Dgeo_0301
TIGRFAM: riboflavin synthase, alpha subunit: (2.4e-59); PFAM: Lumazine-binding protein: (6.1e-25); KEGG: dra:DR0154 riboflavin synthase alpha chain, ev=2e-79, 68% identity.
 
 0.999
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
 
 
 0.999
mscL
Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
  
  
 0.862
Dgeo_1809
TIGRFAM: riboflavin biosynthesis protein RibF: (7.1e-81); PFAM: Riboflavin kinase / FAD synthetase: (9.8e-47); KEGG: dra:DR1008 riboflavin kinase / FMN adenylyltransferase, ev=1e-136, 79% identity; Belongs to the ribF family.
  
  
 0.835
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.817
Dgeo_1498
rRNA methyltransferase, sun family protein; PFAM: Fmu (Sun): (9e-14) NusB/RsmB/TIM44: (4.9e-28); KEGG: dra:DR2168 sun protein, putative, ev=1e-161, 72% identity; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.753
rplU
Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
   
    0.734
nusB
NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
  
  
 0.733
pyrB
KEGG: dra:DR1109 aspartate carbamoyltransferase catalytic chain, ev=1e-149, 86% identity; TIGRFAM: aspartate carbamoyltransferase: (2.7e-112); PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region: (9.4e-27) aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain: (3.6e-50); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
    0.732
Your Current Organism:
Deinococcus geothermalis
NCBI taxonomy Id: 319795
Other names: D. geothermalis DSM 11300, Deinococcus geothermalis AG-3a, Deinococcus geothermalis CIP 105573, Deinococcus geothermalis DSM 11300, Deinococcus geothermalis str. DSM 11300, Deinococcus geothermalis strain DSM 11300
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.